ZYRTEC PILLS 10MG

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ZYRTEC PILLS 10MG

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pharmachologic effect

Antiallergic drug. Histamine H1 receptor blocker, competitive histamine antagonist, hydroxyzine metabolite. Prevents the development and facilitates the course of allergic reactions, has antipruritic antiexudative action.

It affects the early histamine-dependent stage of allergic reactions, limits the release of inflammatory mediators at the late stage of an allergic reaction, reduces the migration of eosinophils, neutrophils and basophils, stabilizes the membranes of mast cells. Reduces capillary permeability, prevents the development of tissue edema, relieves spasm of smooth muscles. Eliminates the skin reaction to the introduction of histamine, specific allergens, as well as cooling (with the "cold" urticaria). Reduces histamine-induced bronchoconstriction in bronchial asthma of the lungs.

Practically no anticholinergic and antiserotonin action. In therapeutic doses, almost no sedative effect.

After a single dose of Cetirizine at a dose of 10 mg, the onset of the effect is observed after 20 minutes (in 50% of patients) and after 60 minutes (in 95% of patients), the effect lasts more than 24 hours. Against the background of course treatment, cetirizine does not develop an antihistamine tolerance. After cessation of treatment, the effect lasts up to 3 days.

Indications

  • treatment of symptoms of year-round and seasonal allergic rhinitis and allergic conjunctivitis, such as itching, sneezing, rhinorrhea, lacrimation, conjunctival hyperemia;
  • hay fever (pollinosis);
  • urticaria (including chronic idiopathic urticaria);
  • angioedema;
  • other allergic dermatoses (including atopic dermatitis), accompanied by itching and rash.

 

Contraindications

  • end-stage renal disease (CC <10 ml / min);
  • pregnancy;
  • lactation period (breastfeeding);
  • hereditary intolerance to galactose, lactase deficiency or glucose-galactose malabsorption syndrome;
  • children's age up to 6 years (for tablets);
  • children up to 6 months (for drops);
  • hypersensitivity to the drug;
  • hypersensitivity to hydroxyzine.
  • Caution should be given to the drug in chronic renal failure (correction of the dosing regimen is required), in chronic liver diseases, in elderly patients (due to a possible decrease in glomerular filtration).
  • Use during pregnancy and lactation
  • The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

 

special instructions

For children aged 6 months to 6 years, Zyrtec is prescribed in the dosage form for oral administration of 10 mg / ml.

Influence on ability to drive motor transport and control mechanisms

In an objective assessment of the ability to drive a motor vehicle and control mechanisms, no adverse reactions were reliably detected when taking the drug at the recommended dose. But, nevertheless, during the period of taking the drug, it is advisable to refrain from engaging in potentially hazardous activities that require increased concentration and psychomotor reactions.

In case of impaired renal function

Caution should be given to the drug in chronic renal failure (moderate or severe severity), as well as to elderly patients (due to a possible decrease in glomerular filtration).

In renal insufficiency, the dose is reduced depending on the CC.

Contraindicated in end-stage renal disease (CC <10 ml / min).

Use in old age

Precautions should be prescribed the drug to elderly patients (due to a possible decrease in glomerular filtration).

Use in childhood

Contraindicated in children under 6 years of age (for tablets), in children up to 6 months (for drops).

Composition

1 tab.

cetirizine dihydrochloride

10 mg

Excipients: microcrystalline cellulose, lactose monohydrate, colloidal silicon dioxide, Magnesium stearate; Opadry Y-1-7000 (hypromellose (E464), titanium dioxide (E171), macrogol 400).

Dosage and administration

The drug is prescribed inside.

Adults and children over 6 years old are prescribed in a dose of 10 mg (1 tab. Or 20 drops) / day.Adults - 10 mg 1 time / day; children 5 mg 2 times / day or 10 mg 1 time / day. Sometimes an initial dose of 5 mg may be sufficient to achieve a therapeutic effect.

Children aged 2 to 6 years old should be prescribed 2.5 mg (5 drops) 2 times / day or 5 mg (10 drops) 1 time / day.

Children aged 1 to 2 years old are prescribed 2.5 mg (5 drops) up to 2 times / day.

Children between the ages of 6 months and 12 months are prescribed 2.5 mg (5 drops) 1 time / day.

In renal failure and in elderly patients, the dose of the drug should be adjusted depending on the size of the CC.

QC can be calculated based on the concentration of serum creatinine according to the following formula:

For men: QC (ml / min) = [140 - age (years)] x body weight (kg) / 72 x serum creatinine (mg / dL);

QC for women can be calculated by multiplying the value obtained by a factor of 0.85.

Adult patients with renal and hepatic insufficiency dose set in the following table.

Renal failure

QC (ml / min)

Dosage and administration

Norm

≥80

10 mg / day

Easy

50-79

10 mg / day

Average

30-49

5 mg / day

Heavy

5 mg every other day

Terminal stage - patients on dialysis

The drug is contraindicated

For patients with impaired liver function, dosing regimen adjustment is not required.

Side effects

From the hemopoietic system: thrombocytopenia.

Nervous system disorders: drowsiness, dizziness, headache, aggression, agitation, confusion, depression, hallucinations, insomnia, tic, convulsions, dyskinesia, dystonia, paresthesia, syncope, tremor.

On the part of the organ of vision: disturbance of accommodation, fuzzy vision, nystagmus.

Cardiovascular: tachycardia.

On the part of the respiratory system: rhinitis, pharyngitis.

On the part of the digestive system: dry mouth, nausea, abdominal pain, diarrhea, abnormal liver function (increased levels of transaminases, ALP, GGT, bilirubin).

On the part of the urinary system: urinary disorders, enuresis.

Allergic reactions: itching, rash, urticaria, angioedema, hypersensitivity, up to the development of anaphylactic shock.

On the part of metabolism: an increase in body weight.

Other: fatigue, asthenia, malaise, edema.

Side effects develop in very rare cases.

Drug interaction

When studying the drug interaction of cetirizine with pseudoephedrine, cimetidine, Ketoconazole, Erythromycin, Azithromycin, glipizide and diazepam, no clinically significant undesirable interaction was revealed.

With simultaneous administration with theophylline (400 mg / day), the total clearance of cetirizine is reduced by 16% (the kinetics of theophylline does not change).

With simultaneous appointment with macrolides and ketoconazole, no ECG changes were observed.

When using the drug in therapeutic doses, data on the interaction with alcohol (with an alcohol concentration in the blood of 0.5 g / l) are not obtained. However, the patient should refrain from drinking alcohol during drug therapy in order to avoid oppression of the central nervous system.

Overdose

Symptoms: when taking the drug once in a dose over 50 mg, confusion, diarrhea, dizziness, fatigue, headache, indisposition, mydriasis, itching, weakness, sedation, drowsiness, stupor, tachycardia, tremor, urinary retention are possible.

Treatment: immediately after taking the drug should be gastric lavage or artificially induce vomiting. It is recommended the appointment of Activated carbon, conducting symptomatic and supportive therapy. There is no specific antidote. Hemodialysis is ineffective.

Storage conditions

Tablets should be stored in their original packaging at a temperature not exceeding 30 ° C. Drops for ingestion should be stored at a temperature not exceeding 25 ° C.

The drug should be kept out of the reach of children.

Shelf life

5 years

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