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Active ingredient and dosage form

solution-drops for oral administration 0.1%
1 ml (20 drops) of solution contains dimetinden maleate 1 mg;
Excipients: methyl parahydroxybenzoate (preservative E 218), ethanol, sodium phosphate dehydrogenated dehydrogenated, sorbitol, purified water;
in vials of 20 ml, in a box 1 bottle.

Mechanism of action

Fenistil is a blocker of histamine H 1 -receptors. It has anti-allergic and antipruritic effect. Significantly reduces the increased capillary permeability associated with allergic reactions. It blocks the action of kinins, has a weak anticholinergic effect, may cause a slight sedation. Antiemetic effect does not have.
With the external use of the drug in the form of a gel, the action begins after a few minutes and reaches a maximum after 2-4 hours.
With prophylactic administration of the drug, a decrease in the severity of hay fever symptoms is noted.

Indications and usage

For oral administration:
- symptomatic treatment of allergic diseases (including urticaria, hay fever, perennial allergic rhinitis, food and drug allergies);
- pruritus of various origin (with the exception of itching associated with cholestasis);
- pruritus in diseases with skin rashes, such as chickenpox;
- insect bites;
- as an adjuvant for eczema and other pruritic dermatoses of allergic origin.


- angle-closure glaucoma (when taken orally);
- urination disorders, incl. with hypertrophy of the prostate gland (by ingestion);
- Hypersensitivity to dimetindenu and other components that make up the drug.
The drug is not prescribed to newborns (especially premature) at the age of 1 month.

Dosage and administration

For adults and children over 12 years old the daily dose is usually 3-6 mg, divided into 3 doses (ie, 20-40 drops 3 times / day).
Patients prone to drowsiness are advised to prescribe 40 drops at bedtime and 20 drops in the morning during breakfast.
Forchildren aged 1 month to 12 years daily doses are shown in the table. The daily dose should be divided into 3 doses.

PatientsDaily dose (drops *)
Children from 1 month to 1 year 10-30
Children from 1 to 3 years 30-45
Children from 3 to 12 years 45-60
Adults 60-120

* 20 drops = 1 ml = 1 mg of dimetinden maleate.
Fenistil drops should not be exposed to high temperatures; they should be added to the bottle with warm baby food just before feeding. If the child is already fed from a spoon, the drops can be given undiluted, with a teaspoon. Drops taste good.

From the side of the central nervous system: often (especially at the beginning of treatment and when used in high doses) - drowsiness; seldom - pronounced dizziness, agitation, headaches.
Gastrointestinal: rarely - gastrointestinal disorders (including nausea), dry mouth.
Respiratory: rarely, dry throat; in isolated cases - respiratory disorders.
Other: in rare cases, edema, skin rash, muscle spasm.

Pregnancy and breastfeeding

Use of Fenistil in pregnancy is possible only for health reasons and under medical supervision.
It is not recommended to prescribe fenistil nursing mothers during lactation.

Special notes

It is not recommended to use Fenistil in patients with bronchial asthma.
Do not use Fenistil simultaneously with anti-depressants, MAO inhibitors (including with nialamide).
Use in pediatrics
Be cautiously prescribed fenistil in the form of a solution-dropschildren under 1 yearbecause they have a sedative effect may be accompanied by episodes of sleep apnea. Haveyoung children Fenistil, like other antihistamines, can cause arousal.
Influence on ability to drive motor transport and control mechanisms
Patients whose activities require increased concentration of attention and quick psychomotor reactions (driving a car, working with mechanisms) are not recommended to take the drug.

Drug Interactions

With the simultaneous appointment with Fenistil drugs that inhibit the central nervous system (including tranquilizers, hypnotic drugs, drugs for anesthesia, as well as ethanol), it is possible to increase the sedative effect of these drugs.
Do not use Fenistil simultaneously with MAO inhibitors (includingnialamide) because of the possible increase in their anticholinergic effects and inhibitory effects on the central nervous system.
With the simultaneous use of tricyclic antidepressants (including Amitriptyline, imipramine) and anticholinergics (including atropine, scopolamine) with phenytille, it is possible to increase the anticholinergic effect.
With the simultaneous use of ethanol and dimeindena increases the inhibitory effect on the central nervous system.

Storage conditions

Store at a temperature not exceeding 30 ° C; protect from light.

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