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Mechanism of action

Dusopharm has a vasodilating effect, as a result of which it improves peripheral and cerebral circulation. It causes a decrease in peripheral vascular resistance and increases the minute volume of the heart, without having a significant effect on heart rate and blood pressure. The vasodilating effect of Dusopharm is the result of its direct myotropic, antagonistic to serotonin 5HT2 receptors and alpha-adreno-blocking action. It has an M-holinoblokiruyuschee effect.

It has a positive effect on cellular metabolism, improving the utilization of oxygen and glucose. This action of the drug is due to its ability to increase ATP levels and inhibit the enzyme succinate dehydrogenase. It activates glucose utilization through the citric acid cycle and increases the conversion of succinic acid to fumaric acid. As a result, the resistance of cells (including the brain) to hypoxia increases.

In addition, Dusopharm reduces increased blood viscosity.


Indications and usage

The recovery period of cerebral circulatory disorders; peripheral circulatory disorders (intermittent claudication, Raynaud's disease, trophic ulcers).



  • Increased individual sensitivity to the drug.
  • Myocardial infarction (acute stage).
  • Hypotension.
  • Hemorrhagic stroke (acute stage).
  • Epilepsy, increased convulsive readiness.
  • Chronic heart failure stage II – III (NYHA stage III – IV - functional classification of heart failure by the New York Heart Association).
  • Tachyarrhythmias.
  • Age up to 18 years (efficacy and safety have not been established).

Carefully: angle-closure glaucoma; prostatic hyperplasia.

Pregnancy and Breastfeeding

Dusopharm does not have a teratogenic effect, but since special studies of its safety in pregnant women have not been conducted, it is recommended to prescribe the drug only in cases where the benefits of treatment for the mother outweigh the potential risk to the fetus.

It is not recommended to take the drug during lactation.


Dusopharm does not adversely affect psychomotor reactions and ability to drive a car. At the beginning of treatment, it is recommended to check the individual tolerability of the drug and to trace the possible hypotensive effect in the respective patients.

The drug contains lactose monohydrate, therefore it is unsuitable for people suffering from lactose deficiency, galactosemia or glucose-galactose malabsorption syndrome.

Patients with celiac disease (gluten enteropathy) should take into account that the composition of the pill includes wheat starch.



1 pill contains:

Active substance: Naftidrofuryl oxalate - 50 mg.

Excipients: lactose monohydrate; microcrystalline cellulose; wheat starch; copovidone; colloidal silicon dioxide; Magnesium stearate; talc.

Shell composition: titanium dioxide; talc; magnesium stearate; macrogol 6000; methacrylic acid and ethyl acrylate copolymer; dye sunny sunset yellow E110.


Inside pills are taken whole, with enough liquid (it is recommended to drink water).

In violation of cerebral circulation: in a daily dose of 300 mg (2 pills 3 times a day).

For violations of peripheral circulation: daily doses - 500-600 mg, divided into 3 doses.

Dusopharm is recommended for long-term oral therapy (up to 6 months). Dose adjustment for renal / hepatic failure is not required.

Adverse reactions

When taken orally in doses of 300 to 600 mg, Dusopharm is well tolerated as a whole.

Possible side effects: nausea, vomiting, epigastric pain, intestinal colic, diarrhea, loss of appetite, headache, dizziness, insomnia, reversible increase in liver enzymes, gastric mucosa, allergic reactions.


Strengthens the hypotensive effect of antihypertensive drugs. In this regard, it is recommended that more frequent control of blood pressure at the beginning of the combined treatment with Dusopharm and antihypertensive drugs at the same time.


Symptoms: increased severity of side effects, ventricular arrhythmia, anxiety, lowering blood pressure, bradycardia.

Treatment: gastric lavage, the appointment of Activated carbon and laxatives, symptomatic treatment. There is no specific antidote.

Storage conditions

Store in a dry, protected from light and out of reach of children at a temperature not exceeding 25 ° C.

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