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Active ingredient

Pyrantel pills:
1 pill contains pyrantel 250 mg;
3 pcs. in a blister, 1 or 2 blisters in a carton box.

suspension for oral administration:
5 ml of suspension contain Pyrantel 250 mg;
10 or 15 ml in dark glass bottles, 1 bottle in a carton box.

Mechanism of action

Pyrantel - antihelminthic drug. Affects the musculature of intestinal nematodes by depolarizing their neuromuscular junction and blockade of cholinesterase action. Active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis. It acts on both mature and immature individuals of both sexes, does not affect the larvae in the migration stage.

Indications and usage

Ascariasis; hookworm; necatoriasis; enterobiasis.

Dosage and administration

Set individually depending on the age and body weight of the patient.
Children from 6 months to 2 years - 125 mg (1/2 tab. Or 1/2 lod.)
children from 2 to 6 years old - 250 mg (1 tab. or 1 bed.)
children from 6 to 12 years old - 500 mg (2 tab. or 2 beds.)
children over 12 years old and adults weighing less than 75 kg - 750 mg (3 tab. or 3 beds.)
Adults with a body weight of more than 75 kg - 1 g (4 tab. Or 4 lodges.)
1 scoop = 5 ml.

When ascariasis and enterobiasis the drug is prescribed once per dose at the rate of 10 mg / kg body weight. In some cases, the use of the drug is acceptable in the minimum dose of 5 mg / kg.
For hookworm administered at a dose of 10 mg / kg / day for 3 days.
In severe forms of necatoria (massive invasions of Necator americanus) administered at a dose of 20 mg / kg / day for 2 days.
The drug is taken during or after a meal, the pill should be thoroughly chewed.

Adverse reactions

Gastrointestinal: nausea, vomiting, diarrhea, stomach pain are possible; seldom -
increased activity of hepatic transaminases.
Nervous system: rarely - headache, dizziness, drowsiness, insomnia, weakness; in some cases - hearing impairment, hallucinations, confusion, paresthesia.
Other: skin rash, fever.


Hypersensitivity to pyrantel.

Pregnancy and breastfeeding

Adequate and strictly controlled studies of the safety of the use of Pirantel during pregnancy and lactation (breastfeeding) was not conducted. Use of the drug in these periods is possible only if the intended benefit to the mother outweighs the potential risk to the fetus or child.
AT experimental studies not established negative effects of Pyrantel on the fetus.

Special notes

With caution should appoint the drug to patients with impaired liver function.
During the treatment of myasthenia gravis, you should not prescribe Pirantel.
The use of Pyrantel does not require the simultaneous appointment of laxatives.
When enterobiasis should be the simultaneous treatment of co-residents. After completion of treatment, it is necessary to conduct a control study of feces for the presence of helminth eggs.
Pyrantel is more effective in infecting duodenal ankylostoma (Ancylostoma duodenale) than American ankylostoma (Necator americanus).
Use in pediatrics
With caution should use the drug in children under 2 years old.
Influence on ability to drive motor transport and control mechanisms
In some cases, on the background of taking the drug may be dizziness, so care should be taken when doing work that requires the speed of psychomotor reactions.

Drug Interactions

With simultaneous use with piperazine, the effect of Pirantel is weakened.
Pharmacokinetic interaction
With the simultaneous use of Pirantel may increase the concentration of theophylline in the blood plasma.

The drug should be stored in a dry, dark place at temperatures not above 25 ° C.


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