POLYDEX WITH PHENYLEPHRINE NASAL SPRAY 15ML

Mechanism of action

Combined drug for local use in otorhinolaryngology. The therapeutic effect of the drug Polydex with phenylephrine is due to the anti-inflammatory effect of Dexamethasone on the nasal mucosa, the antibacterial effect of the antibiotics neomycin and polymyxin B. The combination of these antibiotics expands the range of antibacterial action on most gram-positive and gram-negative microorganisms that cause the same-time-effective in-flow-in-the-way out-and-out-of-the-way out-of-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-the-way out-to-person programs that are used in order to get the most out of the way, in order to create a funky effect on a non-inflammatory effect.
Neomycin active against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae.
Polymyxin B active against gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa.
To the action of these antibiotics are resistant Streptococcus spp. (including Streptococcus pneumoniae) and anaerobic bacteria.
Due to the vasoconstrictor action of phenylephrine, the sensation of nasal congestion is reduced.

Pharmacokinetic studies of the drug Polydex with phenylephrine were not conducted due to low systemic absorption.

Local treatment of rhinopharyngitis and sinusitis.

Adverse reactions

Allergic reactions: in rare cases, skin manifestations.

Contraindications

- suspicion of angle-closure glaucoma or the risk of its occurrence;
- simultaneous use of MAO inhibitors in connection with the risk of increasing blood pressure;
- kidney disease, accompanied by albuminuria;
- pregnancy;
- lactation (breastfeeding);
- children's age up to 2.5 years (due to the high sensitivity to sympathomimetics);
- hypersensitivity to the drug components or other aminoglycosides (streptomycin, kanamycin, gentamicin).

Pregnancy and breastfeeding

The drug Polidex with phenylephrine is contraindicated for use during pregnancy and lactation (breastfeeding).

Special notes

The drug is not prescribed to patients with renal insufficiency.
The drug is used with caution in patients with arterial hypertension, IHD, and hyperthyroidism due to the presence of sympathomimetics.
If the patient’s general condition deteriorates due to an infectious-inflammatory disease, antibiotics can be prescribed for systemic use if necessary.
If you are allergic to neomycin, cross-allergy with aminoglycoside antibiotics is possible.

Overdosage

Due to the low degree of absorption into the systemic circulation, overdose is unlikely.

Drug interaction due to the content of phenylephrine. With simultaneous use of guanethidine and drugs of this group enhance the hypertensive effect of phenylephrine and, due to the decrease in sympathetic tone of guanethidine, prolonged mydriasis is possible.If this combination cannot be avoided, then a doctor’s observation is necessary.

The drug should be stored at a temperature not higher than 25 ° C.