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Dosage form

Rectal suppositories


1 suppository contains: Ketoprofen 100 mg.
Excipients: solid semi-synthetic glycerides, colloidal anhydrous silicon.


In a balloon-free contour package 6 suppositories. In a cardboard bundle 2 packs.

Mechanism of action

Flexen - NSAID, a derivative of propionic acid. It has an analgesic, anti-inflammatory and antipyretic effect. The mechanism of action is associated with inhibition of the activity of COX - the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system, as well as the effect on the biological activity of other neurotropic substances that play a key role in the release of pain mediators in the spinal cord brain). In addition, ketoprofen has anti-bradykinin activity, stabilizes lysosomal membranes, and causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis. Suppresses platelet aggregation.

Indications and usage

Symptomatic treatment of pain syndrome of various genesis, rheumatic and inflammatory diseases, including:
- Osteoarthrosis of different localization.
- Ankylosing spondylitis.
- Gout attack.
- Rheumatoid arthritis and periarthritis.
- Bursitis, tendonitis, tendosynovitis, synovitis.
- Sciatica, sciatica.
- Mialgia.
- Bruises, sprains and muscle strains.
- Phlebitis, superficial thrombophlebitis, lymphangitis.


- Diseases of the digestive tract in the acute phase.
- Severe renal dysfunction.
- Severe abnormal liver function.
- Leukopenia, thrombocytopenia.
- Disorders of blood coagulation.
- Pregnancy.
- Lactation (breastfeeding).
- Children and adolescents up to 15 years.
- Hypersensitivity to ketoprofen, Acetylsalicylic acid or other NSAIDs.
- Hemorrhoids, proctitis.

Pregnancy and Breastfeeding

The use of the drug is contraindicated during pregnancy and during breastfeeding.

Dosage and administration

Rectally 1 suppository 1-2 times / day. The maximum daily dose of the drug should not exceed 300 mg.

Adverse reactions

Gastrointestinal: stomach pain, nausea, vomiting, diarrhea, flatulence are possible; rarely - bleeding in the digestive tract; tenesmus, loose stools.
From the side of the central nervous system: rarely - asthenia, headache, dizziness.
Local reactions: burning.
Other: rarely transient dysuria, skin rash.

Special notes

Flexen is used with caution simultaneously with acetylsalicylic acid and other NSAIDs, lithium preparations, antihypertensive drugs, diuretics, Methotrexate and antidiabetic agents. Against the background of the use of the drug Flexen for systemic use, alcohol should be avoided.

Drug Interactions

Since ketoprofen is largely bound to proteins, doses of anticoagulants, diphenylhydantoin, or sulfur-containing drugs should be reduced.


Treatment: there is no specific antidote; if necessary, conduct symptomatic therapy.

The drug should be stored at a temperature not higher than 25 ° C.

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