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Mechanism of action

NSAIDs, in the structure of which there is a sulfonylide group. Nimesulide is believed to be a selective COX-2 inhibitor. It has a pronounced anti-inflammatory, as well as analgesic and to a lesser extent antipyretic effect. The mechanism of action is associated with inhibition of prostaglandin synthesis. Inhibits the synthesis of prostaglandins in the area of ​​inflammation to a greater extent than in the gastric mucosa or kidneys, which is caused mainly by inhibition of COX-2.

In addition, in the mechanism of the anti-inflammatory action of nimesulide, its ability to suppress the formation of free oxygen radicals (without affecting hemostasis and phagocytosis) and inhibit the release of the myeloperoxidase enzyme is important.

Indications and usage

Osteoarthritis, extra-articular rheumatic diseases, pain and inflammation after surgery, pain and fever in acute inflammatory processes in the upper respiratory tract, pain associated with dysmenorrhea.


Peptic ulcer and duodenal ulcer in the acute phase, acute bleeding from the gastrointestinal tract, moderate and severe liver failure, renal failure (CC less than 30 ml / min), pregnancy, lactation; hypersensitivity to nimesulide and other NSAIDs (including acetylsalicylic acid).

Special notes

Caution should be used orally in patients with impaired renal function, arterial hypertension, cardiac abnormalities, and visual impairment.

When applied externally, the physician must be monitored for the condition of elderly patients with impaired renal function, liver, and congestive heart failure.

When used in pediatrics should use dosage forms intended for children. In children under 6 years of age when nimesulide is used externally, medical supervision is required.

Influence on ability to drive motor transport and control mechanisms

Due to the fact that nimesulide can be dizziness and drowsiness when administered orally, it should be used with caution in patients engaged in potentially hazardous activities that require increased concentration and psychomotor reactions.


1 pill contains:

Active substance: Nimesulide 100 mg

Dosage and administration

Inside adults 100-200 mg 2 times / day, children - 1.5 mg / kg 2-3 times / day.

The maximum dose for children - 5 mg / kg / day in 2-3 doses.

Adverse reactions

On the part of the digestive system: heartburn, nausea, stomach pain; in some cases - tarry stools, melena (associated with bleeding and erosive and ulcerative lesions of the gastrointestinal tract).

From the side of the central nervous system: rarely - headaches, dizziness, drowsiness.

Allergic reactions: skin rash, erythema, urticaria.

Other: rarely - oliguria, fluid retention, local or systemic edema; in some cases - thrombocytopenic purpura.

Drug Interactions

Manifestations of drug interactions are possible with simultaneous ingestion of nimesulide with Digoxin, phenytoin, lithium preparations, diuretics, antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, Methotrexate, oral hypoglycemic agents.

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