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Mechanism of action

Antifungal polyene antibiotic of the macrolide group, which has a wide spectrum of action. It has a fungicidal effect. Natamycin binds sterols of cell membranes, violating their integrity and function, which leads to the death of microorganisms. To natamycin sensitive most pathogenic yeasts, especially Candida albicans. Less sensitive to natamycin dermatophytes. Natamycin resistance is not found in clinical practice.
Natamycin tablets, due to the enteric coating, acts only in the intestine.

Natamycin is practically not absorbed from the gastrointestinal tract. Practically not subjected to systemic absorption when applied to intact skin and mucous membranes.

Indications and usage

- intestinal candidiasis (for tablets);
- vulvovaginal candidiasis (for vaginal suppositories);
- skin and mucous membrane lesions caused by Candida albicans, other yeast, yeast-like or other fungi sensitive to the preparation.

Adverse reactions

Gastrointestinal: nausea, diarrhea (arising in the first days of taking the pills and taking place independently during the course of treatment) are possible.
Local reactions: possible slight irritation, burning sensation (when applying the cream, vaginal suppositories).


- Hypersensitivity to the drug.

Pregnancy and breastfeeding

Pimafucin is allowed during pregnancy and lactation.

Vaginal suppositories under the action of body temperature quickly dissolve, forming a foamy mass, which contributes to the uniform distribution of the active substance. In the case of a chronic or recurrent infection, local treatment may be supplemented with prescription pills and cream.
Cetyl alcohol, which is part of vaginal suppositories, can cause hypersensitivity reactions. During menstruation, suppository therapy is interrupted. During the period of use of suppositories there is no need to exclude sexual contacts.
Use in pediatrics
Pimafucin can be prescribed newborn.


Currently, no cases of overdose of Pimafucin have been reported.

Drug Interactions

Drug interaction of the drug Pimafucin is not described.

Storage conditions

The drug should be stored at a temperature of 15 ° to 25 ° C.

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