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Amphotericin B lyophilized powder for solution for infusion 50,000 IU
1 bottle per pack.

Amphotericin B ointment 30 000 IU
in tubes of 15 and 30 g.

Mechanism of action

Antifungal. Amphotericin B binds to the sterols (ergosterols) of the cell membrane of sensitive fungi. As a result, the permeability of the membrane is disrupted and the intracellular components enter the extracellular space.

GI candidosis, intestinal candidiasis, candidiasis of internal organs, chronic and granulomatous disseminated forms of candidiasis, coccidioidosis, cryptococcosis, histoplasmosis, North American blastomycosis, chromomycosis, mold mycosis, sporotrichosis.

Dosage and administration

Amphotericin B solution in iv drip (20–30 drops / min) for 3–6 hours. Amphotericin B ointment is applied topically, 1–2 times a day in a thin layer (up to 4 times). The course of treatment is at least 10 days.

Adverse reactions

When the / in the introduction:
From the nervous system and sensory organs: headache, polyneuropathy, blurred vision, diplopia.
Since the cardiovascular system and blood (blood, hemostasis): arterial hypo-or hypertension, arrhythmia, ECG changes, anemia, leukopenia, thrombocytopenia.
On the part of the digestive tract: nausea, vomiting, diarrhea, epigastric pain, increased activity of liver enzymes.
From the genitourinary system: impaired renal function, incl. increased serum creatinine concentration, proteinuria, azotemia, acidosis.
Allergic reactions: skin rash, itching, angioedema, bronchospasm (during inhalation).
Others: fever, chills, loss of appetite, impaired blood electrolyte, incl. hypokalemia, hypomagnesemia; thrombophlebitis at the injection site; inhalation may cause sore throat, cough, runny nose.

When applied topically, there are no side effects characteristic of a systemic effect, but allergic reactions may occur.


Individual intolerance to antibiotics, diseases of the liver and kidneys. diseases of the hematopoietic system, diabetes.

Pregnancy and Breastfeeding

With caution during pregnancy (adequate and strictly controlled studies of the safety of use in pregnant women have not been conducted). At the time of treatment should stop breastfeeding (it is not known whether amphotericin B penetrates into breast milk).

In the process of treatment requires systematic monitoring of the function of the kidneys, liver, blood composition and the level of potassium in the blood. If symptoms of anemia appear, treatment with amphotericin B should be discontinued.For better tolerability of the antibiotic, it is recommended to add 10–15 drops of medical glycerin to the solution for inhalation.

Storage conditions

In a dry, dark place at a temperature of 2-10 ° C..

4 years.

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