CLOTRIMAZOLE SOLUTION FOR EXTERNAL USE 1% 15ML

Mechanism of action

Antifungal drug for external use, containing as an active substance Clotrimazole is an imidazole derivative. The mechanism of action is to inhibit the synthesis of ergosterol, necessary for the construction of the cell membrane of fungi, which leads to a violation of its permeability and subsequent cell lysis. It also causes an increase in the permeability of the phospholipid membrane of liposomes, vacuolization of the cytoplasm, and a decrease in the number of ribosomes. It has antibacterial and trichomonacid action.
Active against mushrooms: Epidermophyton, Trichophyton, Microsporum, Candida, Cryptococcus neoformans, Malassezia furfur, Aspergillus, Blastomyces dermatitidis, Coccidioides immitis, Sporothrix schenckii.
Also active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp.

Overdosage

Due to the low absorption of the drug overdose with external use is unlikely.

Drug Interactions

When applied simultaneously with clotrimazole, the effectiveness of other antifungal drugs is reduced.
High concentrations of p-hydroxybenzoic acid propyl ester enhances the antifungal effects of Clotrimazole.
Dexamethasone in high doses inhibits the antifungal action of Clotrimazole.

Storage conditions

The drug should be stored in a dry, dark place. Shelf life - 3 years.

The drug is approved for use as a means of OTC.