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Mechanism of action

Antifungal agent, has activity against dermatophytes, yeast fungi, dimorphic fungi and eumycetes. It is also active against staphylococci and streptococci. The mechanism of action is to inhibit the synthesis of fungi ergosterol. It prevents the transformation of Candida albicans blastospores into invasive forms.

Indications and usage

Fungal infections of the gastrointestinal tract, genital organs, skin, hair (including seborrheic dermatitis), and nails caused by susceptible pathogens. Systemic mycoses. Prevention of fungal infections in patients with an increased risk of their development.


Hypersensitivity, pregnancy, lactation.

Dosage and administration

For ingestion in adults and children weighing more than 30 kg - 200-400 mg / day. Children weighing less than 30 kg - 4-8 mg / kg / day. Take 1 time / day. while eating.

For external and topical administration, the dosing regimen depends on the indications and the dosage form used.

Adverse reactions

Gastrointestinal: in rare cases - nausea, vomiting, diarrhea.

Nervous system: in rare cases - headache, dizziness, sleep disorders, paresthesias.

Dermatologic: in rare cases, rash; very rarely - hair loss.

From the reproductive system: very rarely - gynecomastia, decreased libido, oligospermia.

Allergic reactions: very rarely - urticaria, skin rash.

Other: in rare cases - photophobia, thrombocytopenia; very rarely - arthralgia, fever.


In oral administration, it is necessary to regularly monitor the picture of peripheral blood, the functional state of the liver and kidneys. If GCS was used for the treatment of skin lesions, then Ketoconazole should be prescribed no earlier than 2 weeks later.

Drug Interactions

With the simultaneous use of ketoconazole with rifampicin and isoniazid, a decrease in plasma ketoconazole concentration is noted.

With simultaneous use of ketoconazole with cyclosporine, indirect anticoagulants and methylprednisolone may increase their concentrations in the blood plasma.

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