MEXIDOL AMPOULES 5% 5ML

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MEXIDOL AMPOULES 5% 5ML - 5 pcs

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Active ingredient and dosage form

Mexidol injection 5% colorless or slightly yellowish, transparent.
1 ml of solution contains ethyl methylhydroxypyridine succinate 50 mg;
excipient - water for injection;
in ampoules of 2 or 5 ml, in a package of 5 or 10 ampoules.

Mexidol coated tablets from white to white with a creamy shade of color, biconvex; 2 layers are visible in the cross-section: the inner (core) gray or gray with a creamy tint and the outer white or white with a creamy tint.
1 pill contains ethyl methyl hydroxypyridine succinate 125 mg;
30 or 50 pills per pack.

Mechanism of action

Mexidol is an antioxidant agent. It has a wide range of pharmacological activity: it increases the body's resistance to stress, has an anxiolytic effect, which is not accompanied by drowsiness and muscle relaxant effect. It has a nootropic effect, prevents and reduces the disorders of learning and memory that occur during aging and the effects of various pathogenic factors, has an anticonvulsant effect; has antioxidant and antihypoxic properties, increases concentration and performance; weakens the toxic effect of alcohol.
Mexidol increases the body's resistance to the effects of various damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia, impaired cerebral circulation, intoxication with alcohol and antipsychotic drugs).
Mexidol improves brain metabolism and blood supply to the brain, improves microcirculation and blood rheological properties, and reduces platelet aggregation. Stabilizes membrane structures of blood cells (erythrocytes and platelets). It has a hypolipidemic effect, reduces the content of total cholesterol and LDL.
The mechanism of action of Mexidol is due to its antioxidant and membrane-protective action. It inhibits lipid peroxidation processes, increases the activity of superoxidase, increases the ratio of lipid-protein, reduces the viscosity of the membrane, increases its fluidity. Modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps to preserve the structural and functional organization of biomembranes, and the use of the organomers, as a result of the use of the organomers, as a result of the use of the organomers, as a result of the use of the organomers, as a result of the use of the organomerbane, in addition to the organomers, as a result of the use of the organomegran, organomers, organomers, organomers, and other organisms;
Mexidol increases the content of dopamine in the brain. It causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in ATP and creatine phosphate,activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes.

Indications and usage

  • Consequences of acute movements of the brain fracture, including the consequence of transient ischemic attacks,
    the phase of training in the quality of the clinical results;
  • The bluetontal trauma, the consequences of the craniocerebral trauma;
  • Encephalopathy of various genesis (circulation, dysmetabolic, post-ram, mixed);
  • Syndrome of pediatric dysfunction;
  • Lightweight cognitive abnormalities of the aestroscopic genesis;
  • Emergency Disorders in Neurotic and Neurosis Conditions;
  • Coping with the syndrome of alcoholism with the help of non-violent and vegetative-juridical disputes; post-victimization;
  • Acute intoxication with antipsychotics:
  • Natural conditions, as well as for the prevention of the development of somatic diseases due to the influence of extreme factors and diseases;
  • Extremely Extreme (Stressful) Factors;
  • Acute purulent-inflammatory processes of the abdominal cavity (acute necrolytic pancreatitis, peritonitis) as part of complex therapy.

Contraindications

Acute disorders of the liver and kidneys, increased individual sensitivity to the drug.

Strictly controlled clinical studies of the safety of the drug Mexidol in children, during pregnancy and breastfeeding were not conducted.

Dosage and administration

Mexidol pills are inside. Therapeutic dose and duration of treatment are determined by the sensitivity of patients to the drug.
Begin treatment with a dose of 125-250 mg (1-2 tab.) 1-2 times a day with a gradual increase to obtain a therapeutic effect. The maximum daily dose is 800 mg (6 tablets).
The duration of treatment is 2-6 weeks.
When relieving alcohol withdrawal syndrome Duration of application is 5-7 days.
Treatment is stopped gradually, reducing the dose within 2-3 days.

Mexidol injection
V / m or v / v (jet or drip) - With the infusion method of administration, the drug should be diluted in an isotonic solution of sodium chloride. Jet Mexidol is injected slowly over 5-7 minutes, drip - at a speed of 40-60 drops per minute.
The maximum daily dose should not exceed 1200 mg.

For acute disorders of cerebral circulation, Mexidol is used in the first 10-14 days - in / in the drip, 200-500 mg 2-4 times a day, then - 200-250 mg intramuscularly 2-3 times a day for 2 weeks.

Adverse reactions

Gastrointestinal: rarely - nausea, dry mouth.
Other: rarely - allergic reactions.

Store in a dry place protected from light, at a temperature not exceeding 25 ° C.

Mexidol

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