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Active ingredient and dosage form

Diltiazem pills for oral intake:
1 pill contains diltiazem chloride 60 and 90 mg; 30 pcs in pack.

Mechanism of action

Selective Calcium channel blocker class III, a derivative of benzothiazepine. Diltiazem has antianginal, hypotensive and antiarrhythmic effects. Reduces myocardial contractility, slows AV conductivity, reduces heart rate, reduces myocardial oxygen demand, dilates coronary arteries, increases coronary blood flow. Diltiazem reduces the tone of the smooth muscles of peripheral arteries and round neck. Reduces the intracellular content of calcium ions in cardiomyocytes and smooth muscle cells of blood vessels, reduces heart rate, may have a slight negative inotropic effect, increases coronary, cerebral and renal blood flow. In concentrations where there is no negative inotropic effect, Diltiazem causes relaxation of the smooth muscles of the coronary vessels and dilatation of both large and small arteries. The anti-anginal effect is due to an improvement in the myocardial blood supply and a decrease in its oxygen demand as a result of a decrease in congestion, systemic blood pressure (afterload), a decrease in myocardial tone and an increase in the diastolic relaxation time of the left ventricle.

Prevention of angina attacks (including Prinzmetal angina). Arterial hypertension. Prevention of supraventricular arrhythmias (paroxysmal supraventricular tachycardia, atrial fibrillation, atrial flutter, extrasystole).

Inside, swallowing whole and squeezed fluid. 60 mg 3 times a day or 90 mg 2 times a day. The optimal daily dose of Diltiazem is 180-360 mg. In stationary conditions, under the supervision of a doctor, the dose may be increased to 480 mg / day.

Adverse reactions

Nervous system and sensory organs: headache, dizziness, fainting, fatigue, asthenia, sleep disturbances, drowsiness, anxiety, extrapyramidal (parkinsonian) disorders (ataxia, mask-like face, shuffling gait, stiffness of arms or legs, hand trembling and fingers, difficulty swallowing), depression; when used in high doses - paresthesia, tremor, blurred vision (transient vision loss).

Cardiovascular: asymptomatic reduction of blood pressure; rarely - angina pectoris, arrhythmia (including flutter and ventricular fibrillation), bradycardia (less than 50 beats / min) or tachycardia, AV block II-III st. up to asystole, development or aggravation of heart failure; when used in high doses and with a / in the introduction - angina, bradycardia, AV blockade, marked reduction in blood pressure, aggravation of chronic heart failure.

On the part of the digestive system: dry mouth, increased appetite, nausea, vomiting, constipation or diarrhea, increased activity of liver transaminases, gingival hyperplasia (bleeding, soreness, swelling).

From the hematopoietic system: rarely - thrombocytopenia, agranulocytosis.


Severe bradycardia, AV block II and III degrees (with the exception of patients with a pacemaker), SSS, cardiogenic shock, atrial fibrillation in WPW syndrome and Launa-Ganoga-Levine, myocardial infarction with congestive lung, hypotension, chronic heart failure II Stage B-III, acute heart failure, hemodynamically significant aortic stenosis, abnormal liver and kidney function, pregnancy, lactation, hypersensitivity to benzothiazepine derivatives.

Special notes

Diltiazem is used with caution in AV-blockade I degree, intraventricular conduction disorders, in patients prone to arterial hypotension, chronic heart failure, myocardial infarction with left ventricular failure, ventricular tachycardia with dilated ORS complex, liver failure, renal insufficiency, elderly patients, renal failure, elderly patients., in children (efficacy and safety have not been studied).

Keep out of reach of children at a temperature not exceeding 25 ° C.

Shelf life - 2 years.


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