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Active ingredient and dosage form

Lisinoton - tablets: 1 table. contains lisinopril (in the form of dihydrate) 5, 10 and 20 mg; excipients: mannitol, Calcium hydrogen phosphate dihydrate, pregelatinized corn starch, croscarmellose sodium, Magnesium stearate.; in packing of 28 pieces.

Mechanism of action

Lisinoton has a hypotensive, vasodilator, cardioprotective, nephroprotective effect.

Indications and usage

Arterial hypertension (monotherapy or in combination with other antihypertensive drugs);

chronic heart failure (as part of combination therapy for the treatment of patients taking digitalis and / or diuretics);

acute myocardial infarction (to maintain stable hemodynamic parameters and prevent left ventricular dysfunction and heart failure);

diabetic nephropathy (to reduce albuminuria in insulin-dependent patients with normal blood pressure and insulin-independent patients with arterial hypertension).


Hypersensitivity to lisinopril or other ACE inhibitors;

angioedema in history, including and from the use of ACE inhibitors;

hereditary angioedema;

age up to 18 years (efficacy and safety have not been established).

Pregnancy and Breastfeeding

The use of Lisinotona during pregnancy is contraindicated. When establishing pregnancy, the drug should be stopped as soon as possible. Acceptance of ACE inhibitors in the II and III trimester of pregnancy has an adverse effect on the fetus (pronounced decrease in blood pressure, renal failure, hyperkalemia, hypoplasia of the skull, fetal death) are possible.

Lisinopril penetrates through the placenta. No data on the penetration of lisinopril into breast milk. For the period of treatment with Lizinoton, breastfeeding should be canceled.

Adverse reactions

The most common side effects are dizziness, headache (in 5-6% of patients), weakness, diarrhea, dry cough (3%), nausea, vomiting, orthostatic hypotension, skin rash, chest pain (1-3%).

Rare side effects (

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