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Mechanism of action

Physiotens is a selective imidazoline receptor agonist responsible for tonic and reflex control over the sympathetic nervous system (localized in the ventro-lateral part of the medulla oblongata). Slightly binds to central alpha2-adrenergic receptors, lowers blood pressure. With long-term use, it reduces LV myocardial hypertrophy, eliminates the signs of myocardial fibrosis, microarteriopathy, normalizes the capillary blood supply of the myocardium, reduces CRPS, pulmonary vascular resistance. The treatment reduces the concentration of norepinephrine and epinephrine, renin, angiotensin II at rest and during exercise, atrial natriuretic factor (during exercise), and plasma aldosterone. It reduces tissue resistance to insulin, stimulates the release of growth hormone. Does not affect the exchange of glucose and lipids. The interval between the achievement of Cmax and a pronounced decrease in blood pressure at rest differs on average by 10%, with a load of 7.7%. The duration of action is more than 12 hours (it is slowly excreted from the central nervous system and for a long time reduces the concentration of epinephrine in the plasma).

Indications and usage

Arterial hypertension.


Hypersensitivity, SSSU, SA and AV block, bradycardia (less than 50 / min), decompensated CHF, unstable angina, severe liver failure, CRF (CK less than 30 ml / min, creatinine more than 160 mcmol / l), lactation period. C caution. Parkinson's disease (severe), epilepsy, glaucoma, depression, intermittent claudication, Raynaud's disease; pregnancy, children's age - no experience of use.

Dosage and Administration

The drug should be taken orally, during or after a meal, with a liquid, 0.2 mg / day at a time, preferably in the morning. If necessary, increase the dose to 0.4 mg / day for 2 doses. The maximum daily dose is 0.6 mg. In patients with renal insufficiency (CK 30-60 ml / min), a single dose should not exceed 0.2 mg, daily dose - 0.4 mg.

Special notes

During treatment, regular monitoring of blood pressure, heart rate and ECG is necessary. When QA is below 60 ml / min, the dose is reduced by 2 times, below 30 ml / min - canceled. During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.

Drug Interactions

Strengthens the inhibitory effect on the central nervous system of anxiolytics, barbiturates and ethanol. The resulting effect of the addition of alpha-blockers to therapy is determined by their dose. Mutual enhancement of action with joint appointment with other antihypertensive drugs.Beta-adrenergic blockers enhance bradycardia, the severity of negative insomnia and dromotropic action. If it is necessary to cancel simultaneously taken beta-blockers and Moxonidine, they are the first to cancel beta-blockers and only a few days later moxonidine.

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