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Mechanism of action

ACE inhibitor, antihypertensive drug. The mechanism of action is associated with a decrease in the formation of angiotensin II from angiotensin I. A decrease in the content of angiotensin II leads to a direct decrease in the release of aldosterone, while the congestion of systolic and diastolic BP, post- and preload on the myocardium decreases.

Expands the arteries to a greater extent than the veins, while the reflex increase in heart rate is not observed. Reduces the degradation of bradykinin, increases the synthesis of prostaglandin. The hypotensive effect is more pronounced with a high concentration of renin in the blood plasma than with a normal or reduced concentration. A decrease in blood pressure in the therapeutic range does not affect the cerebral circulation, the blood flow in the vessels of the brain is maintained at a sufficient level and against the background of low blood pressure. Enhances coronary and renal blood flow.

With prolonged use, left ventricular myocardial hypertrophy and myocytes of resistive-type artery walls are reduced, prevents progression of heart failure and slows down the development of left ventricular dilatation. Improves blood supply to ischemic myocardium. Reduces platelet aggregation. Zofenopril is a prodrug, becauseactivity is free sulfhydryl compound (zofenoprilat), formed as a result of thioester hydrolysis.

After ingestion, the hypotensive effect develops after 1 h, reaches a maximum after 4-6 h and lasts up to 24 h. In some cases, therapy for several weeks is necessary to achieve optimal reduction of blood pressure. In heart failure, a noticeable clinical effect is observed with prolonged treatment (6 months or more).


Suction and distribution

After oral administration, zofenopril Calcium is rapidly and completely absorbed from the gastrointestinal tract and undergoes almost complete conversion to zofenoplat.

Cmax of zofenoprilata in blood plasma is reached 1.5 hours after taking Zocardis. Binding to plasma proteins for zofenopril is 88%.

Metabolism and excretion

Zofenopril is rapidly metabolized in the liver to form the active metabolite of zofenoprilat. T1 / 2 zofenoprilat makes 5.5 h, the general clearance makes 1300 ml / min. Zofenoprilat is excreted mainly by the kidneys - 69%, through the intestines - 26%.

Indications and usage

  • mild to moderate hypertension;
  • acute myocardial infarction with symptoms of heart failure in patients with stable hemodynamic parameters and not receiving thrombolytic therapy.

In case of arterial hypertension, in order to achieve an optimal level of blood pressure in adults, therapy should be started at a dose of 15 mg (2 pills of 7.5 mg or 1/2 tablet.30 mg) 1 time / day and gradually, with insufficient severity of the hypotensive effect, increase the dose with an interval of 4 weeks.

The average dose is 30 mg 1 time / day (4 pills of 7.5 mg or 1 pill of 30 mg).

The maximum daily dose is 60 mg (8 tab. 7.5 mg or 2 tab. 30 mg each). The multiplicity of reception 1-2 times / day.

In case of violations of water and electrolyte balance, before the appointment of ACE inhibitors, correction of water and electrolyte metabolism and the cancellation of the therapy with diuretics for 2-3 days before the start of taking the ACE inhibitor is required. In this case, the initial dose of Zocardis is 15 mg / day. If the cancellation of diuretics and the normalization of water-electrolyte balance is impossible, then the initial dose of Zocardis should be 7.5 mg / day.

Correction of the dose of Zocardis is necessary for patients with impaired renal function or on hemodialysis. With QA> 45 ml / min, dose adjustment is not performed; with QC <45 ml / min, the dose should be reduced to 1/2 of the average therapeutic dose 1 time / day.

The initial dose for patients on dialysis is 1/4 of the dose used for patients with normal renal function.

With normal kidney function, dosing regimen adjustment is not required in elderly people.

In patients with mild and moderate hepatic insufficiency, the initial dose of Zocardis is half the dose used in patients with normal liver function.

Patients with severe hepatic impairment do not prescribe Zocardis.

With acute heart attackmyocardium in combination therapy Zocardis is prescribed for 24 hours after the first symptoms of myocardial infarction occur and continue for 6 weeks, using the following scheme:

Period of time

Dosage and administration

1st and 2nd day

7.5 mg every 12 hours

3rd and 4th day

15 mg every 12 hours

from the 5th day onwards

30 mg every 12 hours

With an excessive decrease in blood pressure at the beginning of treatment or during the first 3 days after myocardial infarction, the initial dose is not increased or canceled.

After 6 weeks of treatment, therapy may be discontinued in patients without signs of left ventricular failure or heart failure. For the correction of left ventricular failure or heart failure, as well as hypertension, treatment can be continued for a long time.

Zocardis should be used with caution in patients with myocardial infarction over 75 years.

Tablets are taken orally, regardless of the meal (before, during or after a meal), drinking plenty of fluids.

Adverse reactions

Cardiovascular: excessive reduction of blood pressure, orthostatic collapse; rarely - chest pain, stenocardia, myocardial infarction (usually associated with a pronounced decrease in blood pressure), arrhythmias (atrial brady- or tachycardia, atrial fibrillation), palpitations, pulmonary embolism, pain in the region of the heart, fainting.

CNS and peripheral nervous system: dizziness,headache, weakness, insomnia, anxiety, depression, confusion, fatigue, drowsiness (2-3%); very rarely (when used in high doses) - nervousness, paresthesias.

From the senses: rarely - disorders of the vestibular apparatus, impairment of hearing and vision, tinnitus.

On the part of the digestive system: dry mouth, anorexia, dyspepsia (nausea, diarrhea or constipation, vomiting, pain in the abdomen), increased liver transaminase activity, hyperbilirubinemia, intestinal obstruction, pancreatitis, abnormal liver function, disorders of the biliary tract, hepatitis, jaundice.

On the part of the respiratory system: unproductive dry cough; very rarely - interstitial pneumonitis, bronchospasm, shortness of breath, rhinorrhea, pharyngitis.

On the part of the hematopoietic system: in some cases, thrombocytopenia, neutropenia, agranulocytosis (in patients with autoimmune diseases), eosinophilia.

On the part of the urinary system: increased creatinine and urea, renal dysfunction, proteinuria.

From the laboratory parameters: hyperkalemia, hyponatremia; in some cases - a decrease in hematocrit and hemoglobin, increased ESR.

Allergic reactions: rarely - skin rash, angioedema (face, extremities, lips, tongue, glottis and / or larynx), dysphonia, erythema polymorphic, exfoliative dermatitis; very rarely - Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), pemphigus, pruritus, urticaria, photosensitization, serositis, vasculitis, myositis, arthralgia, arthritis, stomatitis, glossitis.


- angioedema associated with the use of ACE inhibitors, in history;
- porphyria;
- severe liver dysfunction;
- pregnancy;
- lactation (breastfeeding);
- age up to 18 years (efficiency and safety have not been established);
- renal failure severe;
- hypersensitivity to zofenopril and other ACE inhibitors.

Zocardis should be used with caution in primary hyperaldosteronism, bilateral renal artery stenosis, stenosis of a single kidney artery, hyperkalemia, condition after kidney transplantation, aortic stenosis, mitral stenosis (with hemodynamic disorders), idiopathic hypertrophic subaortic stenosis, idiopathic subaortic stenosis, idiopathic hypertrophic subaortic stenosis, with idiopathic subaortic stenosis, idiopathic subaortic stenosis, idiopathic subaortic stenosis, idiopathic subaortic stenosis. diabetes, proteinuria more than 1 g / day, liver failure, while used with immunosuppressants, in individuals n old age (older than 75 years), with psoriasis.

Care must be taken when prescribing the drug to patients with reduced BCC (as a result of diuretic therapy, while limiting salt intake, hemodialysis, diarrhea and vomiting), because increased risk of sudden and pronounced decrease in blood pressure after the use of an ACE inhibitor, even in the initial dose.

Zocardis is contraindicated for use during pregnancy and lactation (breastfeeding).

When using the drug, women of childbearing age should use reliable methods of contraception. Zofenopril calcium is excreted in breast milk.

Newborns and infants whose mothers have taken ACE inhibitors are recommended to be closely monitored for the timely detection of marked reduction in blood pressure, oliguria, hyperkalemia, and neurological disorders, possibly due to a decrease in renal and cerebral blood flow while reducing the blood pressure caused by ACE inhibitors. In oliguria, it is necessary to maintain blood pressure and renal perfusion by injecting appropriate fluids and vasoconstrictor agents.

Symptoms: pronounced decrease in blood pressure (up to the development of collapse, myocardial infarction, acute cerebrovascular accident or thromboembolic complications), convulsions, stupor.

Treatment: the patient is transferred to a horizontal position with a low head. In mild cases - gastric lavage and ingestion of saline, in more severe cases - measures aimed at stabilizing blood pressure (in / in the introduction of a 0.9% sodium chloride solution, plasma substitutes); if necessary, the introduction of angiotensin II, hemodialysis.

A transient pronounced decrease in blood pressure is not a contraindication for the continuation of drug treatment after stabilization of blood pressure.In case of repeated pronounced decrease in blood pressure, reduce the dose or discontinue the drug.

The use of high-flow dialysis membranes increases the risk of Anaphylactic reactions. Correction of the dosing regimen on dialysis-free days should be carried out depending on the level of blood pressure.

When using the drug, it is necessary to carefully monitor patients with heart failure, coronary heart disease and cerebrovascular diseases, in whom a sharp decrease in blood pressure can lead to myocardial infarction, stroke or renal dysfunction.

Sudden cancellation of treatment does not lead to withdrawal syndrome (a sharp rise in blood pressure).

In patients with angioedema in the history of anamnesis, there is an increased risk of its development when taking ACE inhibitors.

The patient should be warned about the need to be careful when doing physical exercises in hot weather (the risk of dehydration and an excessive decrease in blood pressure due to a decrease in BCC).

Before performing surgical interventions (including dental) it is necessary to warn the surgeon / anesthesiologist about the use of ACE inhibitors.

During the use of the drug treatment is not recommended to drink alcohol.

Control of laboratory parameters

Before and after treatment with ACE inhibitors, control of blood pressure, hemoglobin, potassium, creatinine, urea, liver enzyme activity, and protein content in the urine is necessary.

Influence on ability to drive motor transport and control mechanisms

During the selection of a therapeutic dose, it is necessary to refrain from engaging in potentially hazardous activities that require increased concentration of attention and psychomotor speed, since dizziness is possible (especially after taking the initial dose of an ACE inhibitor while using diuretics).

When combined, the hypotensive effect of ACE inhibitors can be enhanced by other antihypertensive drugs, diuretics, general anesthesia drugs, analgesics, antipyretics, ethanol.

With simultaneous appointment with NSAIDs, the hypotensive effect of zofenopril may be reduced; with potassium-sparing diuretics - hyperkalemia; with lithium salts - slowing down the removal of lithium.

With the combined use of immunosuppressants, Allopurinol, cytotoxic drugs increase the hematotoxicity of zofenopril, hypoglycemic agents increase the risk of hypoglycemia.

List B. The drug should be kept out of the reach of children at a temperature not exceeding 25 ° C. Shelf life - 3 years.

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