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Active ingredient

Tablets included: pills of two types:
pills white, round, biconvex, with risk:
1 tab. contains Enalapril maleate 20 mg,
Excipients: lactose monohydrate; Magnesium carbonate; gelatin; crospovidone; magnesium stearate

coated tablets white, round, biconvex:
1 tab. contains Indapamide 2.5 mg,
 lactose monohydrate; Povidone K30; crospovidone; magnesium stearate; sodium lauryl sulfate; talc; hypromellose; macrogol 6000; titanium dioxide;
45 pcs. (30 +15) in the package.

Mechanism of action

Enzix duo forte has an antihypertensive effect.

Indications and usage

Arterial hypertension.

Hypersensitivity to the drug; pregnancy; lactation period; children and adolescents up to 18 years;
history of angioedema associated with treatment with ACE inhibitors; renal insufficiency (Cl creatinine> 30 ml / min);

Indapamide: anuria; hypokalemia; severe liver failure (including with encephalopathy); severe renal failure; simultaneous use of drugs that extend the QT interval.

Dosage and administration

Enzix duo forte is taken orally, in the morning, at the same time 1 tab.enalapril (20 mg) and 1 tab. indapamide (2.5 mg), in the evening 1 tab. enalapril (20 mg).

The maximum daily dose of enalapril is 40 mg, indapamide - 2.5 mg.

In chronic renal failure, the dose of enalapril should be 5-10 mg / day.

Adverse reactions

From the side of the central nervous system and peripheral nervous system: headache, dizziness, weakness, insomnia, anxiety, confusion, fatigue, drowsiness (2-3%); in some cases, when high doses are used, nervousness, depression, paresthesias.

On the part of the respiratory system: unproductive dry cough, interstitial pneumonitis, bronchospasm, shortness of breath, rhinorrhea, pharyngitis.

From the senses: disorders of the vestibular apparatus, hearing and vision impairment, tinnitus.

Gastrointestinal: dry mouth, anorexia, dyspeptic phenomena (nausea, diarrhea or constipation, vomiting, abdominal pain), intestinal obstruction, pancreatitis, abnormal liver function and biliary excretion, hepatitis, jaundice, increased activity of hepatic transaminases, hyperbilirubinemia.

Cardiovascular: excessive blood pressure reduction, orthostatic collapse; rarely - chest pain, angina pectoris, myocardial infarction (usually associated with a pronounced decrease in blood pressure), arrhythmias (atrial brady- or tachycardia, atrial fibrillation), palpitations, thromboembolism of the pulmonary artery branches, pain in the heart, fainting.

From the water and electrolyte exchange: hyperkalemia, hyponatremia.

From the hemopoietic system: rarely - decrease in hematocrit and hemoglobin concentration, thrombocytopenia, neutropenia, agranulocytosis (in patients with autoimmune diseases), eosinophilia, increased ESR.

Allergic reactions: skin rash, angioedema of the face, extremities, lips, tongue, glottis and / or larynx, dysphonia, erythema polymorphic, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, pemphigus, pruritus, urticaria, serositis, vasculitis, myositis, myositis, myelosis, itching, urticaria, serositis, vasculitis, myositis, myositis, myelosis, pemphigus, pruritus, urticaria, serositis, vasculitis, myositis, myositis, myelosis, pemfigus, pruritus, urticaria, serositis, vasculitis, myositis, myositis, myelosis, pemphigus, pruritus, urticaria, serositis, myositis, arthritis, stomatitis, glossitis.

Dermatologic: alopecia, photosensitivity.

From the urinary system: impaired renal function, proteinuria, hypercreatininemia, increased urea.

From the reproductive system: decreased libido, hot flashes.

Storage conditions

Keep out of reach of children at temperature not exceeding 20 ° С.

Enzix duo

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