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Active ingredient and dosage form

Cordinorm - tablets, film-coated: 1 table. contains Bisoprolol fumarate 5 and 10 mg; excipients: MCC; mannitol; croscarmellose sodium; Magnesium stearate; hypromellose; titanium dioxide; macrogol 6000; in the package 30 pcs.

Mechanism of action

Cordinorm has antianginal, antiarrhythmic, hypotensive effect.

Indications and usage

Arterial hypertension;

IHD (prophylaxis of strokes).


Hypersensitivity to bisoprolol or to any of the components of Cordinorm, other beta-blockers;

shock (including cardiogenic);


pulmonary edema;

acute heart failure;

chronic heart failure in the stage of decompensation;

AV blockade 2-3 degrees (without pacemaker);

sinoatrial blockade;

sick sinus syndrome;

severe bradycardia (heart rate <50 beats / min);

Prinzmetal angina pectoris;

cardiomegaly (without signs of heart failure);

arterial hypotension (SAD <100 mmHg, especially in myocardial infarction);

a history of bronchial asthma and COPD;

simultaneous administration of MAO inhibitors (with the exception of MAO-B);

late stages of impaired peripheral circulation;

Raynaud's disease;

pheochromocytoma (without the simultaneous use of alpha-blockers);

metabolic acidosis;

age up to 18 years (efficacy and safety have not been established).

Pregnancy and Breastfeeding

Application Cordinorm during pregnancy and breastfeeding is possible if the benefits to the mother outweigh the risk of side effects in the fetus and child.

Adverse reactions

Nervous system disorders: fatigue, weakness, dizziness, headache, drowsiness or insomnia, “nightmarish” dreams, depression, anxiety, confusion or short-term memory loss, hallucinations, asthenia, myasthenia gravis, paresthesias in the extremities (in patients with “intermittent "Limp and Raynaud's syndrome), tremor.

On the part of the senses: blurred vision, decreased secretion of the tear fluid, dry and sore eyes, conjunctivitis.

Cardiovascular: sinus bradycardia, palpitations, myocardial conduction disturbances, AV block (up to the development of complete transverse blockade and cardiac arrest), arrhythmias, weakening of myocardial contractility, development (worsening) of chronic heart failure, reduction of blood pressure, orthostatic hypotension manifestation of angiospasm (increased disturbance of peripheral circulation, cooling of the lower extremities, Raynaud's syndrome), chest pain.

On the part of the gastrointestinal tract: dryness of the oral mucosa, nausea, vomiting, abdominal pain, constipation or diarrhea, abnormal liver function (dark urine, jaundice of sclera or skin, cholestasis), changes in taste.

On the part of the respiratory system: nasal congestion, difficulty breathing when administered in high doses (loss of selectivity) and / or in predisposed patients - laryngo and bronchospasm.

On the part of the endocrine system: hyperglycemia (in patients with non-insulin-dependent diabetes mellitus), hypoglycemia (in patients receiving insulin), a hypothyroid state.

Allergic reactions: itching, rash, urticaria.

On the part of the skin: increased sweating, skin flushing, rash, psoriasis-like skin reactions, exacerbation of symptoms of psoriasis, alopecia.

Laboratory indicators: thrombocytopenia (unusual bleeding and hemorrhage), agranulocytosis, leukopenia, changes in the activity of enzymes, the level of bilirubin and triglycerides.

Effect on the fetus: intrauterine growth retardation, hypoglycemia, bradycardia.

On the part of the musculoskeletal system: muscle weakness, cramps in the calf muscles.

Others: back pain, arthralgia, decreased libido; rarely, a decrease in potency, the syndrome of "cancellation" (increased angina attacks, increased blood pressure).

Dosage and administration

Cordinorm taken orally, in the morning on an empty stomach, without chewing, 2.5-5 mg once. Usually the initial dose is 5 mg once a day. If necessary, increase the dose to 10 mg 1 time per day. The maximum dose for adults is 20 mg / day.

In patients with severe impaired renal function (Cl creatinine <20 ml / min) or with severe impaired liver function, the maximum daily dose is 10 mg.Dose adjustment in elderly patients is not required.

Storage conditions

In the dark place at a temperature of no higher than 25 ° C. Shelf life - 2 years.

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