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- arterial hypertension (both in monotherapy and in combination with other antihypertensive drugs / thiazide diuretics, beta-blockers, slow Calcium channel blockers or ACE inhibitors /);

- benign prostatic hyperplasia (both in the presence of arterial hypertension and in normal blood pressure).

Dosage and administration

The drug is prescribed by mouth 1 time / day (in the morning or in the evening), regardless of the meal, without chewing and drinking plenty of water.

At hypertension The initial daily dose is 1 mg at bedtime.

After taking the first dose, the patient should be in bed for 6-8 hours. This is necessary due to the possibility of the development of the "first dose phenomenon", especially against the background of previous diuretics.

With a lack of therapeutic effect after 1-2 weeks, the daily dose can be increased to 2 mg. Subsequently, every 1-2 weeks, you can increase the dose by 2 mg. In most patients, the optimal therapeutic effect is achieved with a daily dose of 8 mg. The maximum daily dose is 16 mg.

After reaching a stable therapeutic effect, the dose is usually reduced (the average therapeutic dose with maintenance therapy is usually 2-4 mg / day).

At benign prostatic hyperplasia Artezin® prescribed in the initial dose of 1 mg / day. If necessary, increase the dose to 2-4 mg / day. The maximum daily dose is 8 mg.

The duration of treatment is long and is determined by the attending physician.

Adverse effects

Arterial hypertension

In clinical trials, orthostatic hypotension, which in rare cases can lead to syncope, has been observed most often, especially at the beginning of treatment.

Cardiovascular: swelling, fainting.

Nervous system: dizziness, headache, drowsiness.

Gastrointestinal: nausea.

Respiratory: rhinitis.

General reactions: asthenia, fatigue, malaise.

The following side effects were also noted in patients with arterial hypertension (the causal relationship with taking the drug has not been established): bradycardia, tachycardia, palpitations, chest pain, angina, myocardial infarction, impaired cerebral circulation, arrhythmia.

Benign prostatic hyperplasia

In patients with benign prostatic hyperplasia, the same side effects as in patients with arterial hypertension, as well as:

Since the cardiovascular system: decrease in blood pressure, orthostatic hypertension.

Nervous system: dry mouth, priapism, hypesthesia, paresthesia, tremor, impotence, insomnia, irritability.

On the part of the endocrine system: gynecomastia.

Gastrointestinal: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, loss of appetite, nausea, increased activity of hepatic transaminases, cholestasis, jaundice, hepatitis.

From the side of blood-forming organs: leukopenia, purpura, thrombocytopenia.

Musculoskeletal system: arthralgia, muscle cramps, muscle weakness, myalgia.

Respiratory: bronchospasm, cough, shortness of breath, epistaxis.

Dermatologic: alopecia.

Special senses: blurred vision, tinnitus.

Urogenital: dysuria, hematuria, urination disturbance, nocturia, polyuria, urinary incontinence.

Allergic reactions: skin rash, urticaria.

Other: pain in the back, sensation of heat (flushing of the skin of the face).


- age up to 18 years (efficacy and safety have not been established) - for pills 2 mg and 4 mg;

- Hypersensitivity to Doxazosin, a derivative of quinazolone or other components of the drug.

WITH caution the drug should be used for aortic and mitral stenosis, orthostatic hypotension, abnormal liver function, in patients under the age of 18 years (efficacy and safety have not been established) for 1 mg tablets.

Use during pregnancy and lactation

To date, experience with the drug Artezine ® during pregnancy and during breastfeeding in patients with arterial hypertension is not enough. Therefore, despite the absence of teratogenic and embryotoxic effects according to experimental studies, Artezine® It can be prescribed during pregnancy and during breastfeeding only after a careful assessment of the expected benefits of therapy for the mother and the possible risk to the fetus or infant.

Application for violations of the liver

WITH caution should use the drug for violations of the liver.

Application for violations of kidney function

Studies of the pharmacokinetics of doxazosin in patients with kidney disease did not reveal significant pharmacokinetic differences.

Use in children

Contraindication: age up to 18 years (efficacy and safety have not been established) - for pills of 2 mg and 4 mg.

Special notes

Particular caution should be exercised in the appointment of the drug to patients with impaired liver function, especially in cases where at the same time drugs are used that can adversely affect liver function. In cases of deterioration of the functional status of the liver, the drug should be canceled.

In order to prevent orthostatic reactions, patients should avoid unexpected and abrupt changes in body position (moving from a prone position to a standing position).

Before starting treatment, it is necessary to exclude malignant tumors of the prostate gland.

The effect of the first dose is especially pronounced against the background of previous diuretic therapy and a sodium restricted diet.

Taking alcohol can increase undesirable reactions.

Influence on ability to drive motor transport and control mechanisms

Due to the fact that the drug is capable of causing orthostatic reactions at the beginning of treatment or during the period of increasing doses, it is advisable for patients to refrain from all potentially dangerous activities, in particular from driving vehicles and other vehicles and mechanisms.


Symptoms: marked decrease in blood pressure, sometimes accompanied by fainting.

Treatment: the patient must be given a horizontal position with raised legs. Symptomatic therapy is performed. Hemodialysis is ineffective.

Drug interaction

Doxazosin enhances the hypotensive effect of antihypertensive drugs (when used in combination, dose adjustment is required).

There was no adverse interaction with simultaneous use of doxazosin and thiazide diuretics, Furosemide, beta-blockers, slow calcium channel blockers, ACE inhibitors, antibiotics, oral hypoglycemic agents, indirect anticoagulants and uricosuric agents.

The drug does not affect the degree of binding to plasma proteins Digoxin and phenytoin.

With simultaneous use of enzymes of microsomal oxidation in the liver, induction of doxazosin may be reduced, with inhibitors, an increase.

Cimetidine increases doxazosin AUC.

NSAIDs (especially indomethacin), estrogens and sympathomimetic agents can reduce the hypotensive effect of doxazosin.

By eliminating the alpha-adrenostimulating effects of epinephrine, doxazosin can lead to the development of tachycardia and arterial hypotension.

Caution must be exercised when used concomitantly with phosphodiesterase inhibitors (agents for treating erectile dysfunction), since in some patients the hypotensive effect may increase.

Terms and conditions of storage

List B. The drug should be stored in a dry, dark place and out of reach of children at a temperature not exceeding 25 ° C.

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