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Mechanism of action

Trimetazidine is an antihypoxic drug. It has antianginal, antihypoxic action. Directly affecting the cardiomyocytes and neurons of the brain, optimizes their metabolism and function. The cytoprotective effect is due to an increase in energy potential, activation of oxidative decarboxylation and rationalization of oxygen consumption (increased aerobic glycolysis and blockade of fatty acid oxidation). Supports myocardial contractility, prevents a decrease in the intracellular content of ATP and phosphonocreatin. Under conditions of acidosis, it normalizes the functioning of membrane ion channels, and prevents the accumulation of Calcium and sodium in cardiomyocytes. normalizes the intracellular content of potassium ions. Reduces intracellular acidosis and phosphate content due to myocardial ischemia and reperfusion. Interferes with the damaging effects of free radicals, preserves the integrity of cell membranes, prevents activation of neutrophils in the ischemic zone, increases the duration of electrical potential, reduces the release of creatine phosphokinase from cells and the severity of ischemic myocardial damage.

When angina reduces the frequency of attacks (reduced consumption of nitrates), after 2 weeks of treatment increases exercise tolerance, reduced blood pressure drops. Hearing and results of vestibular samples in patients are improved, dizziness and tinnitus are reduced.

When vascular pathology of the eye restores the functional activity of the retina.

Coronary heart disease: prevention of strokes (in combination therapy):
Chorioretinal vascular disorders
Vertigo of vascular origin
Cochleo-vestibular disorders of the ischemic nature (tinnitus, hearing loss).


Hypersensitivity to any component of the drug;
Renal failure (creatinine clearance below 15 ml / min);
Severe abnormal liver function;
Breastfeeding period:
Age up to 18 years (efficacy and safety have not been established).

Dosage and administration

Inside 1 pill 2 times a day, with meals in the morning and evening. The course of treatment is recommended by the doctor.

Adverse reactions

Allergic reactions (pruritus) to the drug or any of its components. Rarely, mild disorders of the gastrointestinal tract, such as gastralgia, nausea and vomiting.

Special notes

On the background of drug treatment in patients with coronary artery disease there is a significant decrease in the daily need for nitrates.

Storage conditions

Store in a dry, dark place at a temperature not exceeding 25 ° C.Keep out of the reach of children.

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