DOXAZOSIN PILLS 2MG
DOXAZOSIN PILLS 2MG - 30 TABS
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1 pill contains Doxazosin mesilate 2.43 mg (based on the base - 2 mg)
Mechanism of action
Hypotensive, vasodilator, lipid-lowering, antispasmodic. Doxazosin selectively blocks postsynaptic alpha1-adrenoreceptors. Due to the decrease in muscle tone of blood vessels, it reduces OPS and lowers blood pressure. Decreases plasma triglycerides, total cholesterol and HDL cholesterol. At the same time, there is a slight increase in the HDL coefficient in relation to total cholesterol (by 4-13%). Doxazosin inhibits platelet aggregation and increases the content of active plasminogen in the tissues. Reduces the tone of smooth muscle cells of the stroma and the capsule of the prostate gland, as well as the bladder neck. Doxazosin lowers resistance and pressure in the urethra, reduces the resistance of the internal sphincter.
Indications and usage
Arterial hypertension (monotherapy and in combination with other antihypertensive drugs: thiazide diuretics, beta-blockers, Calcium channel blockers or ACE inhibitors), benign prostatic hyperplasia (in the presence of arterial hypertension and with normal blood pressure).
Hypersensitivity, pregnancy, breastfeeding, age up to 18 years.
Dosage and administration
Doxazosin Sandoz is taken orally, regardless of the meal, without chewing and drinking plenty of water, 1 time per day (in the morning or in the evening). The initial dose is 1 mg 1 time per day (before bedtime), after which the patient should stay in bed for 6-8 hours (the development of the “first dose” phenomenon, especially expressed against the background of prior diuretic administration) is possible. With a lack of therapeutic effect, the daily dose of Doxazosin is increased to 2 mg only after 1-2 weeks of continuous treatment, then with an interval of 1-2 weeks, the dose is increased by 2 mg to achieve the optimal therapeutic effect.
When using Doxazosin Sandoz, especially at the beginning of treatment, orthostatic hypotension is most often observed, which in rare cases can lead to fainting. In order to prevent orthostatic hypotension, patients should avoid unexpected and abrupt changes in body position (moving from a prone position to a standing position). There may be: headache, dizziness, general feeling of weakness, increased fatigue, drowsiness, rhinitis, nausea. Patients with arterial hypertension are rarely observed: tachycardia, arrhythmia, chest pain, angina attacks, myocardial infarction, cerebrovascular disorders. There have been isolated cases of allergic reactions (skin rash, jaundice, thrombocytopenic purpura, elevated transaminase level, transyamnaz,) priapism, urinary incontinence,increase appetite, constipation, diuresis, myalgia, arthralgia.
Doxazosin is carefully prescribed for pulmonary edema caused by aortic or mitral stenosis; failure of the right ventricle of the heart due to lung embolism or pericardial effusion; left ventricular failure with low filling pressure; cardiac output failure.
Strengthens the severity of the action of antihypertensive drugs (using a combination with them requires dose adjustment). Adverse interactions with simultaneous use of doxazosin and antibiotics, oral hypoglycemic drugs, indirect anticoagulants and uricosuric drugs have not been observed. Does not affect the degree of binding to plasma proteins Digoxin, phenytoin, Indomethacin. With simultaneous use with inducers of microsomal oxidation in the liver, it is possible to increase the effectiveness of doxazosin, with inhibitors - a decrease. Cimetidine increases doxazosin AUC. NSAIDs (especially indomethacin), estrogens (fluid retention) and sympathomimetic drugs may reduce the hypotensive effect of doxazosin. Eliminating the alpha-adrenostimulating effects of epinephrine can lead to the development of tachycardia and hypotension.
Symptoms: marked decrease in blood pressure, sometimes accompanied by fainting.
Treatment: lay the patient on his back, raising his legs; symptomatic therapy.Dialysis is ineffective.
The drug should be stored out of reach of children at a temperature not exceeding 25 ° C.