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pills white, flat-cylinder, with a chamfer.
1 pill contains Amlodipine (in the form of besylate) 5 mg or 10 mg;
: potato starch, lactose, microcrystalline cellulose, Magnesium stearate, Calcium stearate.
10, 20 or 30 pills per pack.

Mechanism of action

- selective calcium channel blocker class II. Antihypertensive effect due to a direct relaxing effect on vascular smooth muscle. It is assumed that the antianginal effect of amlodipine is associated with its ability to expand peripheral arterioles; this leads to a decrease in OPSS, reflex tachycardia does not occur. As a result, there is a decrease in myocardial oxygen demand and energy consumption by the heart muscle. On the other hand, amlodipine, apparently, causes the expansion of large-caliber coronary arteries and coronary arterioles in both intact and ischemic myocardial regions. This provides oxygen to the myocardium during spasms of the coronary arteries.

Arterial hypertension (including as part of combination therapy), stable angina, unstable angina (including angina Printsmetal).


Severe arterial hypotension.Hypersensitivity to dihydropyridine derivatives.

Dosage and administration

For adults, by ingestion, the initial dose is 5 mg 1 time / day. If necessary, the dose may be increased.
Maximum dose: when ingestion - 10 mg / day.

Adverse reactions

Cardiovascular: peripheral edema, palpitations, hyperemia of the skin are possible; when used in high doses - arterial hypotension, arrhythmias, shortness of breath.
Gastrointestinal: nausea, abdominal pain; rarely - gingival hyperplasia.
From the side of the central nervous system: possible headache, fatigue, drowsiness, dizziness.
Allergic reactions: skin rash, itching.

Pregnancy and breastfeeding

The safety of using amlodipine during pregnancy and lactation has not been established. Application is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus or child.

With caution used for violations of the liver, with stenosis of the mouth of the aorta, with chronic heart failure. Patients with impaired renal function, as well as elderly patients do not need to reduce the dose. Perhaps the use of amlodipine for the treatment of patients with dilated (non-ischemic) cardiomyopathy, accompanied by severe form of chronic heart failure.
Clinical data on the use of amlodipine in children are not available.

Drug Interactions

With simultaneous use Amlodipine with other antihypertensive drugs may increase hypotensive action; with means for inhalation anesthesia - possibly increased hypotensive action; with lithium preparations - manifestations of neurotoxicity are possible, incl. nausea, vomiting, diarrhea, ataxia, tremors and / or tinnitus; with sympathomimetics, hypotensive action may be reduced. Indomethacin and other NSAIDs can reduce the hypotensive effect of amlodipine, inhibiting the synthesis of prostaglandins in the kidneys and / or causing fluid retention.

Storage conditions

Store in a dry place at a temperature not exceeding 25 ° C, in places inaccessible to children.
Shelf life - 2 years.


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