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Active ingredient and dosage form

Tablets, film coated, prolonged action: 1 tab. Felodipine contains 2.5 mg, 5 mg and 10 mg; in plastic bottles of 30 pieces.

Mechanism of action

Hypotensive, antianginal. Plendil blocks Calcium channels, inhibits the entry of calcium ions into smooth muscle cells of arterial vessels, causes their expansion, reduces the round focal system, lowers blood pressure, afterload on the heart, increases coronary blood flow, improves the balance of oxygen supply / consumption of myocardium.

Indications and usage

Arterial hypertension, angina pectoris.


Hypersensitivity, decompensated heart failure, acute myocardial infarction, unstable angina, pregnancy, child age.

Dosage and administration

Plendil is recommended to be taken orally in the morning with water. pills should not be broken, crushed or chewed. Plendil can be taken on an empty stomach or after a light breakfast that does not contain large amounts of fat or carbohydrates.

The initial dose is 5 mg 1 time per day. If necessary, the dose may be increased or another antihypertensive drug added. The usual maintenance dose of Plendil is 5 to 10 mg 1 time per day.Elderly patients should consider starting treatment with a daily dose of 2.5 mg.

Adverse reactions

Often (more than 1%): headache, flushing, peripheral edema. Sometimes (0.1-1%): tachycardia, palpitations, fatigue, dizziness, paresthesia, nausea, rash, itching. Rarely (0.01-0.1%): fainting, vomiting, arthralgia, myalgia, sexual dysfunction, impotence, urticaria. Very rarely (less than 0.01%): gingival hyperplasia, elevated liver enzymes, photosensitization, pollakiuria, allergic reactions (fever, angioedema).

Drug interactions

Biotransformation inhibitors (cimetidine) increase plasma concentration, stimulants (phenytoin, Carbamazepine, barbiturates) decrease.

Storage conditions

At temperatures not above 25 ° C.


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