RIBOXIN AMPOULES 2% 10ML

Composition

Coated tablets: 
1 pill contains 0.2 g of inosine;
10, 20, 30, 40, 50 pcs. packaged.
Solution for injection 2%:
1 ml of solution contains 20 ml of inosine;
in 5 or 10 ml ampoules, in a package of 10 ampoules.

A drug that improves metabolism and energy supply of tissues, reduces tissue hypoxia.

Mechanism of action

It is a derivative of purine. Inosine can be considered as a precursor of ATP. It has an anabolic effect. It activates myocardial metabolism. Inosine increases the activity of a number of enzymes of the Krebs cycle, stimulates the synthesis of nucleotides. It inhibits the process of destruction of the ischemic cardiomyocytes sarcolemma and provides intracellular transport of energy. By improving microcirculation, the drug reduces the size of the zone of necrosis and myocardial ischemia.

Well absorbed in the digestive tract. It is destroyed in the liver with the formation of glucuronic acid and its subsequent oxidation. In small quantities excreted in the urine.

Riboxin is prescribed to adults in the treatment of ischemic heart disease, myocardial dystrophy, after myocardial infarction, and cardiac arrhythmias caused by the use of cardiac glycosides.
Prescribed for hepatitis, cirrhosis, fatty liver caused by alcohol or drugs, and urokoproporfirii.
As a means of pharmacological protection of the kidneys from ischemia with a temporary shutdown of the kidney from blood circulation.
The drug improves the visual function of open-angle glaucoma with normalized under the influence of antihypertensive therapy intraocular pressure.

Contraindications

Hypersensitivity to the drug.

Dosage and administration

Riboxin is prescribed orally before meals.
In the first days of treatment, Riboxin is prescribed for 1 tab. 3-4 times a day (600-800 mg). With good tolerance, the dose of the drug is increased within 2-3 days to 1.2-2.4 g per day. The duration of the course of the drug is 4-15 weeks.
With the lessroproporphyria Riboxin is prescribed on 1 tab. 4 times a day. Duration of treatment is 1-3 months.

Riboxin 2% solution is administered intravenously. Enter slowly in a jet or drip (40-60 drops in 1 minute).
Treatment begins with the introduction of 10 ml (200 mg) 1 time per day. With good tolerance, the dose can be increased to 20 ml (400 mg) 1-2 times a day. The duration of treatment is 10-15 days.
For drip, dilute the solution of riboxin in an isotonic solution of sodium chloride or 5% glucose solution to 250 ml.

Adverse reactions

Are possible allergic reactions in the form of urticaria, pruritus, hyperemia of the skin (the drug is canceled).
Seldom: increased concentration of uric acid in the blood.
With prolonged use: exacerbation of gout is possible.

Special notes

Riboxin is not used for emergency correction of disorders of the heart.

Drug Interactions

When used as part of complex therapy, Riboxin contributes to increasing the effectiveness of antiarrhythmic, antianginal and inotropic drugs.
Clinically significant interaction of Riboxin with drugs of other groups is not described.

Storage conditions

List B. In a dry, dark place at room temperature. Keep out of reach of children.

Riboxin