RENIPRIL GT PILLS 10 MG/12.5 MG
RENIPRIL GT PILLS 10 MG/12.5 MG - 20 tabs
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Mechanism of action
RENIPRIL GT - antihypertensive drug, ACE inhibitor. The mechanism of action of Enalapril is associated with inhibition of ACE activity, which reduces the formation of angiotensin II, which contributes to the narrowing of blood vessels, and simultaneously activates the formation of kinins and prostacyclin, which have vasodilating action. Enalapril belongs to prodrugs, after its hydrolysis enalaprilat is formed in the body, which inhibits this enzyme. Enalapril also has some diuretic effect associated with moderate inhibition of aldosterone synthesis. Along with a decrease in blood pressure, the drug reduces the pre- and afterload on the myocardium in heart failure, improves blood circulation in the small circle and respiratory function, reduces resistance in the kidney vessels, which helps normalize blood circulation in them.
Indications and usage
- various forms of arterial hypertension (including renovascular);
- chronic heart failure (as part of combination therapy).
- angioedema associated with the use of ACE inhibitors (in history);
- progressive azotemia in bilateral stenosis of the renal arteries or stenosis of the artery of a single kidney;
- lactation (breastfeeding);
- Hypersensitivity to enalapril and other components of the drug;
- hypersensitivity to other ACE inhibitors.
Dosage and administration
Renipril prescribed by mouth regardless of the meal.
In the treatment of essential arterial hypertension, the initial dose of Renapril is 10-20 mg / day. In the future, the dose is selected individually.
With moderate hypertension enough dose of 10 mg / day. The maximum daily dose is 80 mg.
Renovascular hypertension Renipril prescribed in smaller doses. The initial dose is usually 5 mg / day, then the dose is selected individually. The maximum dose is 20 mg / day.
In case of heart failure, Renipril is prescribed starting from 2.5 mg, then the dose is gradually increased to 10-20 mg (1-2 times / day).
The duration of treatment depends on the effectiveness of the therapy.
In all cases, with a too pronounced decrease in blood pressure, the dose of the drug is gradually reduced.
The drug is used both in monotherapy, and in combination with other antihypertensive drugs.
In patients with impaired renal function, a single dose should be reduced or intervals should be extended.
With the simultaneous appointment of Renipril and NSAIDs may decrease the effectiveness of Renipril; with potassium-sparing diuretics (spironolactone, triamteren,amiloride) - development of hyperkalemia is possible; with lithium salts - slowing down the elimination of lithium (shown to control the concentration of lithium in the blood plasma).
With simultaneous use with antipyretic analgesics may decrease the effectiveness of Renapril.
Renipril weakens the effect of drugs containing theophylline.
Cimetidine lengthens the action of Renipril.
The simultaneous use of Renipril with diuretics, beta-blockers, methyldopa, nitrates, Calcium channel blockers, hydralazine, prazozin enhances the hypotensive effect.
Ethanol enhances the antihypertensive effect of the drug.
Symptoms: arterial hypotension.
Treatment: place the patient in a position with raised legs. In mild cases, appoint saline solution. In more severe cases, in a hospital setting, measures are taken to stabilize blood pressure: IV injection of saline or plasma substitutes. Perhaps the use of hemodialysis.