LISORETIC PILLS 10MG + 12.5MG
LISORETIC PILLS 10MG + 12.5MG - 28 tABS
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Active ingredient and dosage form
Lisoretic - tablets:
1 tab. contains lisinopril 10 and 20 mg, hydrochlorothiazide 12.5 mg, excipients: Calcium phosphate, mannitol, corn starch, pregelatinized starch, ferric oxide red, ferric oxide yellow, Magnesium stearate, purified water; Pack of 10, 14, 20, 28, 30 or 42 pcs.
Mechanism of action
Lisoretic has an antihypertensive, diuretic effect.
Indications and usage
Arterial hypertension (in patients for whom combination therapy is indicated).
Hypersensitivity to Lisoretic, other ACE inhibitors and sulfonamide derivatives;
severe renal insufficiency (Cl creatinine <30 ml / min.);
angioedema (including and in history with the use of ACE inhibitors);
hemodialysis using high-flow membranes;
age up to 18 years (efficacy and safety have not been established).
Pregnancy and Breastfeeding
The use of Lisoretic during pregnancy is contraindicated. When establishing pregnancy, the drug should be stopped as soon as possible. Acceptance of inhibitors in the II and III trimester of pregnancy has an adverse effect on the fetus (pronounced decrease in blood pressure, renal failure, hyperkalemia, cranial hypoplasia, fetal death are possible). Data on the negative effects of Lisoretic on the fetus in the case of use during the first trimester is not. For newborns and infants who have undergone intrauterine effects of ACE inhibitors, it is recommended to monitor for the timely detection of pronounced reduction in blood pressure, oliguria, hyperkalemia. For the period of drug treatment, it is necessary to cancel breastfeeding.
The most common side effects are dizziness, headache.
Other adverse events
Cardiovascular: marked reduction in blood pressure, chest pain; rarely - orthostatic hypotension, tachycardia, bradycardia, the appearance of symptoms of heart failure, impaired AV conduction, myocardial infarction.
On the part of the digestive tract: nausea, vomiting, abdominal pain, dry mouth, diarrhea, dyspepsia, anorexia, change in taste, pancreatitis, hepatitis (hepatocellular and cholestatic), jaundice.
On the part of the skin: urticaria, increased sweating, photosensitivity, pruritus, hair loss.
On the part of the nervous system: mood lability, impaired concentration, paresthesia, fatigue, drowsiness, jerky muscles of the limbs and lips; rarely - asthenic syndrome, confusion.
On the part of the respiratory system: dyspnea, bronchospasm, apnea.
On the part of the hemopoietic system: leukopenia, thrombocytopenia, neutropenia, agranulocytosis, anemia (decrease in hemoglobin, hematocrit, erythrocytopenia).
Allergic reactions: angioedema of the face, extremities, lips, tongue, epiglottis and / or larynx, skin rashes, itching, fever, vasculitis, positive reactions to antinuclear antibodies, increased ESR, eosinophilia.
From the genitourinary system: uremia, oliguria / anuria, impaired renal function, acute renal failure, reduced potency.
Laboratory indicators: hyperkalemia and / or hypokalemia, hyponatremia, hypomagnesemia, hypochloremia, hypercalcemia, hyperuricemia, hyperglycemia, increased levels of urea and creatinine in the blood plasma; hyperbilirubinemia, hypercholesterolemia, hypertriglyceridemia, decreased glucose tolerance, increased activity of hepatic transaminases, especially with a history of kidney disease, diabetes mellitus and renovascular hypertension.
Other: dry cough, arthralgia, arthritis, myalgia, fever, impaired fetal development, exacerbation of gout.
Dosage and administration
Take orally 1 tab. Lisoretic 10 mg + 12.5 mg 1 time / day. If necessary, the dose can be increased to 1 table. Lisoretic 20 mg + 12.5 mg 1 time per day.
Doses for renal failure:
In patients with CC more than 30 and less than 80 ml / min, the drug can be used only after titration of the dose of the individual components of the drug. The recommended initial dose of lisinopril for uncomplicated renal failure is 5-10 mg.
Prior diuretic therapy:
Symptomatic hypotension may occur after taking the initial dose of the drug.Such cases are more common in patients who have had a loss of fluid and electrolytes due to previous treatment with diuretics. Therefore, it is necessary to stop taking diuretics 2-3 days before the treatment with Lisoretic.
In the dark place at a temperature of no higher than 15 ° C. Shelf life - 2 years.