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LODOZ PILLS 5 MG + 6.25 MG - 30 TABS



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Active ingredient and dosage form

Lodoz - coated tablets: 1 table. contains Bisoprolol fumarate (2: 1) 2.5, 5 and 10 mg, hydrochlorothiazide 6.25 mg, excipients: Magnesium stearate; crospovidone; corn starch; corn starch, pre gelatinized; microcrystalline cellulose (MCC); Calcium phosphate monosubstituted; cover: polysorbate 80VS; iron oxide yellow; macrogol 400; titanium dioxide; hypromellose 2910/3; hypromellose 2910; in a package of 30, 50 or 100 pcs.

Mechanism of action

Lodoz has a beta-adrenolytic, diuretic effect.

Indications and usage

Arterial hypertension mild and moderate severity.


Hypersensitivity to bisoprolol and other components of Lodoz;

Hypersensitivity to sulfonamides, incl. hydrochlorothiazide;

severe forms of bronchial asthma, COPD;

chronic heart failure in the stage of decompensation, not amenable to drug therapy;

cardiogenic shock;

sick sinus syndrome, including sinoatrial block;

AV block II and III degree without artificial pacemaker;

severe bradycardia (heart rate less than 50 beats per minute);

variant angina (Prinzmetal angina);

pheochromocytoma (without the simultaneous use of alpha-blockers);

severe forms of peripheral circulatory disorders, including Raynaud's disease;




severe renal impairment (Cl creatinine less than 30 ml / min);

severe abnormal liver function;

simultaneous reception with flaktafenin, sultoprid, antiarrhythmic drugs, lithium;

age up to 18 years (efficacy and safety of Lodoz not established).

Pregnancy and Breastfeeding

Apply Lodoz during pregnancy is not recommended, because it contains a diuretic from the thiazide group.

It is currently unknown whether bisoprolol is excreted in breast milk. Diuretics from the group of thiazides are excreted in breast milk, and therefore breastfeeding during treatment with Lodoz is contraindicated.

Adverse reactions

Lodosis is usually well tolerated.

Side effects are described in less than 10% of cases. These include: feeling cold and numbness of the limbs; sleep disorders, depression; nausea, vomiting, diarrhea, constipation; hypertriglyceridemia and hypercholesterolemia, hyperglycemia and glycosuria, hyperuricemia, disturbance of the water-electrolyte state, metabolic alkalosis; muscle weakness and cramps; bradycardia, impaired AV conduction, exacerbation of chronic heart failure, orthostatic hypotension; bronchospasm in patients with bronchial asthma or a history of COPD; reversible increases in plasma creatinine and urea levels; elevated levels of liver enzymes - asparagintransferase and alanine transferase, hepatitis, jaundice; impotence; hearing impairment, allergic rhinitis; reduced secretion of the lacrimal glands (it is necessary to take into account, patients using contact lenses), visual impairment; leukopenia, thrombocytopenia; beta-blockers can cause or aggravate the course of psoriasis or cause psoriasis-like rashes, alopecia.

Also possible: fatigue, fatigue, dizziness, headache, which may occur at the beginning of treatment and usually disappear during the first or second week of treatment.

Dosage and administration

Inside Lodoz is recommended to be taken in the morning (during the meal). pills must be swallowed whole, with a small amount of liquid and not chewed.

For individual dose selection, Lodoz is available in the following dosages, containing: 2.5 mg of bisoprolol and 6.25 mg of hydrochlorothiazide; 5 mg bisoprolol and 6.25 mg hydrochlorothiazide; 10 mg bisoprolol and 6.25 mg hydrochlorothiazide.

The initial dose corresponds to 1 tab., Containing 2.5 mg of bisoprolol and 6.25 mg of hydrochlorothiazide, 1 time per day.

In case of insufficient efficacy of treatment, the dose is increased to 1 tab., Containing 5 mg of bisoprolol and 6.25 mg of hydrochlorothiazide, 1 time per day. If necessary, the dose can be increased to 1 tab., Containing 10 mg of bisoprolol and 6.25 mg of hydrochlorothiazide, 1 time per day.

Storage conditions

In a dry, dark place at a temperature of no higher than 25 ° C.

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