ISOKET CONCENTRATE FOR THE SOLUTION OF AMPOULE 1 MG/ML 10 ML
ISOKET CONCENTRATE FOR THE SOLUTION OF AMPOULE 1 MG/ML 10 ML - 10 pcs
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Mechanism of action
Peripheral vasodilator with a predominant effect on the venous vessels. Antianginal agent. The mechanism of action is associated with the release of the active substance nitric oxide in the smooth muscles of the blood vessels. Nitric oxide causes activation of guanylate cyclase and increases the level of cGMP, which ultimately leads to relaxation of vascular smooth muscle. The action of isosorbide dinitrate is mainly associated with a decrease in myocardial oxygen demand due to a decrease in preload (dilation of peripheral veins and a decrease in blood flow to the right atrium) and afterload (decrease in OPS), as well as direct coronary dilating. It promotes the redistribution of coronary blood flow in the ischemic areas.
Each time you press the sprayer an equal amount of solution is sprayed in the form of tiny droplets in the mouth. Isosorbide dinitrate easily penetrates through the mucous membrane of the mouth and very quickly (after a few seconds) enters the bloodstream.
Indications and usage
- relief of angina attacks;
For relieving angina pectoris or for the prevention of its occurrence (before physical or emotional stress) The aerosol is sprayed in the oral cavity 1-3 times (at a dose of 1.25-3.75 mg) with an interval of 30 seconds between injections. The maximum single dose is 3.75 mg (3 injections), the excess of which is possible only in exceptional cases.
Cardiovascular: It is possible (at the first use or when the dose is increased) a decrease in blood pressure, orthostatic hypotension (with reflex tachycardia, lethargy, as well as dizziness and a feeling of weakness), "nitrate" headaches (arising at the beginning of treatment and disappearing, usually with further use of the drug ); rarely, increased symptoms of angina (with a marked decrease in blood pressure); in rare cases, collaptoid states, sometimes with bradycardia and syncope.
- vascular collapse;
Pregnancy and breastfeeding
During pregnancy and lactation, the drug is prescribed only in cases where the intended benefit to the mother outweighs the potential risk to the fetus or child due to the lack of sufficient clinical experience of its use during these periods.
With caution and under close medical supervision, the drug is used in acute myocardial infarction with a reduced ventricular filling pressure (a decrease in systolic blood pressure below 90 mm Hg should be avoided); with hypertrophic obstructive cardiomyopathy, constrictive pericarditis, cardiac tamponade, with aortic or mitral stenosis; with diseases accompanied by increased intracranial pressure; in patients with a tendency to orthostatic reactions.
Symptoms: may increase the described side effects.
With simultaneous use with phosphodiesterase-5 inhibitors (for example, sildenafil), hypotensive effect may be enhanced (this combination is contraindicated.)
The aerosol form of izoket should be kept out of the reach of children at room temperature.