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COAPROVEL PILL 300MG/12.5MG - 28 tabs



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Active ingredient and dosage form

Coaprovel - tablets:

1 pill contains irbesartan 150 and 300 mg, hydrochlorothiazide 12.5 mg, excipients: microcrystalline cellulose, croscarmellose sodium, lactose monohydrate, Magnesium stearate, hydrated colloidal silicon dioxide, pregelatinized corn starch, ferric oxide red, ferric oxide yellow; Pack of 14, 28, 56 or 98 pcs.

Mechanism of action

Coaprovel has a hypotensive effect.

Indications and usage

Arterial hypertension.


- II and III trimesters of pregnancy;

- hypersensitivity to the components of Coaprovel;

- hypersensitivity to other drugs derived sulfonamida.

To use hydrochlorothiazide:

- renal failure severe (CC <30 ml / min);

- refractory hypokalemia, hypercalcemia;

- severe form of liver failure;

- biliary cirrhosis;

- cholestasis.

Adverse reactions

From the hemopoietic system: aplastic anemia, bone marrow depression, hemolytic anemia, leukopenia, neutropenia / agranulocytosis, thrombocytopenia.

From the side of the central nervous system and peripheral nervous system: depression, sleep disturbances, dizziness, paresthesias, anxiety.

On the part of the organ of vision: transient blurred vision, xantopsia.

Cardiovascular: arrhythmias, postural hypotension.

On the part of the respiratory system: respiratory distress syndrome (including pneumonitis and pulmonary edema).

On the part of the digestive system: jaundice (intrahepatic cholestatic jaundice).

Allergic reactions: Anaphylactic reactions, toxic necrosis of the epidermis, skin reactions such as lupus erythematosus, necrotized angiitis (vasculitis, skin vasculitis), photosensitivity reactions, rash, exacerbation of skin manifestations of lupus erythematosus, urticaria.

From the musculoskeletal system: muscle spasms, weakness.

On the part of the urinary system: interstitial nephritis, renal dysfunction.

Other: fever.

On the part of laboratory parameters: electrolyte imbalance (including hypokalemia and hyponatremia), glycosuria, hyperglycemia, hyperuricemia, increased cholesterol and TG.

Dosage and administration

Co-cap can be applied 1 time / day. before or during meals in patients whose blood pressure is not sufficiently controlled by irbesartan or hydrochlorothiazide separately.

Coaprovel150 / 12.5 mg is prescribed to patients in whom BP is not sufficiently controlled by hydrochlorothiazide or irbesartan (150 mg / day) during monotherapy.

Coaprovel 300 / 12.5 mg is prescribed to patients whose blood pressure is not sufficiently controlled by irbesartan (300 mg) or Coaprovel (150 / 12.5 mg).

Use of the drug in doses of more than 300 mg of irbesartan / 25 mg of hydrochlorothiazide 1 time / day. not recommended.

Storage conditions

In the dark place at a temperature of no higher than 25 ° C. Shelf life - 3 years.

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