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Active ingredient and dosage form

Pills white or almost white flat-cylindrical shape. (Amlodipine besyat in terms of Amlodipine 5 - 10 mg)
30 pieces packaged.

Mechanism of action

Antianginal, hypotensive. Amlotop, by binding to dihydropyridine receptors, blocks Calcium channels, reduces the transmembrane transition of calcium ions into the cell (to a greater extent in vascular smooth muscle cells than cardiomyocytes).

Indications and usage

Arterial hypertension (monotherapy or in combination with other antihypertensive drugs); angina (including angina, vasospastic stenocardia (Prinzmetal stenocardia); silent myocardial ischemia, decompensated chronic heart failure (adjuvant therapy).

Dosage and administration

The initial dose Amlotop - 5 mg 1 time per day; maximum dose - 10 mg 1 time per day


Hypersensitivity including to other dihydropyridine derivatives, severe hypotension, collapse, cardiogenic shock, pregnancy and lactation, age up to 18 years (efficacy and safety have not been established).
With caution: abnormal liver function, sick sinus syndrome (severe bradycardia, tachycardia), decompensated chronic heart failure, mild or moderate arterial hypotension, aortic stenosis, mitral stenosis, hypertrophic obstructive cardiomyopathy, acute myocardial infarction (and within 1 month), and during the course of 1, and during the course of the year 1, and during the course of the disease, myocardial heart failure, diabetes, impaired lipid profile, advanced age.

Adverse reactions

Since the cardiovascular system: palpitations, shortness of breath, marked reduction in blood pressure, fainting, vasculitis, edema (ankles and feet), "flushes" of blood to the face; rarely - rhythm disturbances (bradycardia, ventricular tachycardia, atrial flutter), chest pain, orthostatic hypotension; very rarely - the development or aggravation of heart failure, extrasystoles, migraine.
From the side of the central nervous system: headache, dizziness, fatigue, drowsiness, mood changes, convulsions; rarely - loss of consciousness, hypesthesia, nervousness, paresthesia, tremor, vertigo, asthenia, malaise, insomnia, depression, unusual dreams; very rarely - ataxia, apathy, agitation, amnesia.
On the part of the digestive tract: nausea, vomiting, epigastric pain; rarely, pancreatitis, dry mouth, flatulence, gingival hyperplasia, constipation or diarrhea; very rarely - gastritis, increased appetite.
On the part of the urogenital system: rarely - pollakiuria, painful urge to urinate, nocturia, impaired sexual function (including reduced potency); very rarely - dysuria, polyuria.
For the skin: very rarely xerodermia, alopecia, dermatitis, purpura, discoloration of the skin.
Allergic reactions: pruritus, rash (including erythematous, maculopapular, urticaria), angioedema.
On the part of the musculoskeletal system: rarely - arthralgia, arthrosis, myalgia (with prolonged use); very rarely - myasthenia

Special notes

During the period of treatment, control over body weight and sodium consumption, the appointment of an appropriate diet is necessary. Tooth hygiene should be maintained and the dentist visited frequently (to prevent soreness, bleeding and gum hyperplasia). Dosing regimen for the elderly is the same as for patients of other age groups. With increasing doses, Amlotop requires careful monitoring of elderly patients. The drug does not affect plasma concentrations of K +, glucose, triglycerides, total cholesterol, LDL, uric acid, creatinine and urea nitrogen.

The drug should be stored in a dry, dark place at a temperature not higher than 25 ° C.


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