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Active ingredient and dosage form

Injection: 1 ampoule with 1 ml of p-ra contains a standardized, defatted and deproteinized extract from 4 species of marine fish 10 mg (active substance), excipients: phenol, water for injection;
5 ampoules in a blister, 2 blisters in a box.

Mechanism of action

A drug Alflutop regulates metabolism in cartilage tissue. The composition of the extract of marine fish includes glycosaminoglycans: hyaluronic acid, chondroitin-6-sulfate, chondroitin-4-sulfate, dermatan sulfate, keratan sulfate; amino acids; polypeptides (with a molecular weight of 50,000 daltons); macro- and microelements: sodium, potassium, Calcium, Magnesium, iron, zinc, copper.
Alflutop has a chondroprotective effect based on the inhibition of the activity of hyaluronidase and other enzymes that are involved in the destruction of the extracellular matrix and the normalization of the biosynthesis of hyaluronic acid and type II collagen. These effects are synergistic and determine the activation of cartilage structure restoration processes and prevent the destruction of the macromolecular structures of normal cartilage tissues.
Alflutop, restoring homeostasis in the joint, inhibits the biosynthesis of inflammatory mediators, including proinflammatory cytokines.As a result, it has a pronounced anti-inflammatory and analgesic effect, which is manifested at 8-10 days of treatment.
The proteoglycans that make up Alflutop have a trophic effect and have a substitute effect, significantly increasing the MRI of hydrophilicity, height of cartilage, and bone homogeneity.
In diseases of the gastrointestinal tract Alflutop has a gastroprotective effect. The drug restores the synthesis of prostaglandins, reduces the time of epithelialization of ulcerative and erosive defects in NSAID-gastropathies on the background of anti-ulcer therapy. It can serve as a drug of choice in patients with advanced NSAID gastropathy, if it is necessary to continue analgesic and anti-inflammatory therapy.

Adverse Effects

Seldom: itchy dermatitis, redness of the skin, burning sensation at the injection site, short-term myalgia.
In some cases: transient increase in pain syndrome (with intra-articular injection due to the activation of metabolism and intensification of blood circulation).


- pregnancy;
- lactation.

There is evidence of the effectiveness of intramuscular paravertebral administration of Alflutop in the treatment of patients with spinal osteochondrosis with radicular and non-crack pain syndromes in both exacerbations and in partial or complete remission.
Use in pediatrics
The prescription of Alflutop in childhood and adolescence is not recommended due to the lack of clinical data confirming the safety and efficacy of its use in this age group.

Drug interactions drug Alflutop not installed.

Alflutop should be stored in a cool, dark place at a temperature of 8 ° to 15 ° C.

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