KOSILON SOLUTION 5% 60ML

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KOSILON SOLUTION 5% 60ML

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Indications for use

Androgenic alopecia in men and women (in order to restore hair or stabilize the process of hair loss).

Pharmacokinetics

When applied externally, Minoxidil is poorly absorbed through normal, intact skin: an average of 1.5% (0.3-4.5%) of the total applied dose enters the systemic circulation. When applied topically, the concentration of minoxidil in serum is determined by the rate of its absorption through the skin.

The profile of the metabolic biotransformation of minoxidil after external use of the drug Kosilon has not yet been fully studied.

Minoxidil does not bind to plasma proteins and is excreted by the kidneys through glomerular filtration. Minoxidil does not penetrate the blood-brain barrier.

Excreted mainly with urine. Minoxidil and its metabolites are excreted by hemodialysis.

Clinical Pharmacology

When external use of minoxidil, its stimulating effect on hair growth in individuals with androgenic alopecia (thinning hair, baldness) was noted. It improves microcirculation, stimulates the transition of hair cells to the active growing phase, changes the effect of androgens on the hair follicles. Reduces the formation of 5-alpha-dehydrotestosterone (possibly mediated), which plays a significant role in the formation of baldness.The best effect has a small duration of the disease (no more than 10 years), young patients, a bald spot in the region of the crown not more than 10 cm, the presence in the center of the baldness more than 100 vellus and terminal hair.

The exact mechanism of action of minoxidil as a hair growth stimulator in patients with androgenetic alopecia is unknown.

The appearance of signs of hair growth is noted after 4 months or more of the drug. The onset and severity of the effect may vary in different patients. After the cessation of the use of the drug Kosilon, the growth of new hair stops, within 3-4 months it is possible to restore the original appearance.

Minoxidil is ineffective in the case of baldness caused by taking the drug, malnutrition (iron deficiency (Fe), vitamin A), as a result of styling the hair in "tight" hairstyles.

Pregnanacy and breastfeeding

It should not be used during pregnancy and lactation (breastfeeding).

Contraindications

  • Hypersensitivity to minoxidil.
  • Violation of the integrity of the skin.
  • Dermatosis of the scalp.
  • Pregnancy.
  • Lactation period.
  • Children and adolescents up to 18 years.
  • Older age - over 65 years.

Adverse Effects

Temporary

The use of minoxidil can cause increased hair loss during the transition from the resting phase to the growth phase, with old hair falling out and new ones growing in their place.This temporary phenomenon is usually observed 2-6 weeks after the start of treatment and gradually stops over the next two weeks (the appearance of the first signs of the action of minoxidil).

Local

Side effects from external use can manifest as pruritus at the site of application, contact dermatitis, folliculitis, hypertrichosis (unwanted body hair growth, including facial hair growth in women), seborrhea.

If the drug is accidentally swallowed, the following symptoms may occur.

On the part of the skin

Non-specific allergic reactions (skin rash, urticaria).

On the part of the respiratory system

Dyspnea, allergic rhinitis.

The nervous system

Headache, Dizziness, Vertigo, Neuritis.

Since the cardiovascular system

Chest pain, fluctuations in blood pressure, rapid heartbeat, changes in the rhythm of heart contractions, edema.

Interaction

There is a theoretical possibility of enhancing orthostatic hypotension in patients receiving concomitant treatment with peripheral vasodilators, which, however, has not received clinical confirmation. We can not exclude a very slight elevated content of minoxidil in the blood of patients suffering from hypertension and taking minoxidil orally in the case of simultaneous use of the drug Kosilon, although the corresponding clinical studies have not been conducted.

It is established that minoxidil when applied topically may interact with some other drugs for external use.

The simultaneous use of a solution of minoxidil for external use and a cream containing betamethasone (0.05%) leads to a decrease in systemic absorption of minoxidil.

When applied simultaneously to the skin of minoxidil and topical preparations containing tretinoin, anthralin / dithranol (which cause a change in the protective function of the skin), may increase the absorption of minoxidil.

Overdosage

Accidental intake of Kosilon may cause systemic side effects due to the vasodilating properties of Minoxidil (5 ml of Kosilon contains 250 mg of Minoxidil, which is 2.5 times the maximum recommended dose for adults when taken orally for the treatment of hypertension).

  • Symptoms: fluid retention, lower blood pressure, tachycardia.
  • Treatment: to eliminate fluid retention, diuretics can be prescribed if necessary; for the treatment of tachycardia - beta-blockers. For the treatment of arterial hypotension, a 0.9% solution of sodium chloride should be injected intravenously. You should not prescribe symptomatic agents, such as norepinephrine and epinephrine, with excessive cardiac stimulating activity.

Dosage and administration

Outwardly.

Before using the sprayer for the first time, spray the solution 2-3 times until a uniform spray is achieved. The next time the sprayer can be used immediately.

Regardless of the size of the treated area, apply 1 ml of the solution with a dispenser (8 taps) 2 times a day to the affected areas of the scalp, starting from the center of the affected area.

Wash hands after use.

The total daily dose should not exceed 2 ml.

Cosylon is most effective:

  • For men - with hair loss at the crown.
  • For women - with hair loss in the middle parting.

Apply the drug Kosilon only on dry skin of the scalp.

The solution does not require rinsing.

The appearance of the first signs of hair growth stimulation is possible after using the drug 2 times a day for 4 months or more.

After clinical improvement, the dose is reduced to 1 ml solution 1-2 times a week.

The onset and severity of hair growth, as well as the quality of hair can vary in different patients. According to single reports, within 3-4 months after cessation of treatment, the initial appearance can be restored.

The duration of treatment is on average about 1 year.

If after 4 months a satisfactory result is not achieved, you should consult with a dermatologist, who may decide to extend the treatment.

Precautionary measures

For external use only.

Before you start treatment with Kosilon, patients must undergo a general examination, including the collection and examination of medical history. The physician must ensure that the scalp is healthy.If systemic side effects or severe skin reactions occur, patients should discontinue the drug and consult a doctor.

Kosilon applied only to the skin of the scalp. Do not apply kosilon on other parts of the body!

In addition to hereditary predisposition hair loss may be due to other reasons. Kosilon does not prevent hair loss caused by:

  • Some drugs.
  • Eating disorders (lack of iron or vitamin A in the body).
  • As well as hair loss as a result of styling in tight hair (tail, beam).

Before using the drug Kosilon, it is necessary to consult a doctor if:

  • Hair loss began suddenly.
  • Baldness is focal.
  • There is a cardiovascular pathology.

You should stop using the drug Kosilon and you should consult with your doctor if:

  • The appearance of chest pains.
  • Palpitations.
  • Dizziness or Fainting
  • Lower blood pressure.
  • A sudden increase in weight and swelling of the arms and / or legs.
  • Redness or irritation at the rubbing point.

Cosillon contains alcohol, which causes irritation of the mucous membrane of the eyes. In case of accidental contact of the drug with sensitive areas (eyes, damaged skin, mucous membranes), flush the affected area with plenty of cold water.

Some patients after the use of the drug was observed to change the color and structure of the hair.Flushing of the drug should be avoided. If possible, apply Kosilon on a dry head after washing or wait about 4 hours after applying the preparation before washing. Do not let your head get wet earlier than 4 hours after applying the drug.

Hairspray and other hair care products can be used during the period of use of the drug Kosilon. Before applying hair care products, you must first apply Kosilon and wait until the treated area of ​​skin is completely dry.

There is no evidence that dyeing hair, performing a perm or using hair softeners may in any way reduce the effectiveness of the drug. However, to prevent possible irritation of the scalp, it is necessary to make sure that Kosilon was completely washed away from the hair and scalp before using these chemicals.

Use Kosilon only in accordance with the instructions.

Influence on ability to manage transport and work on machines

The effect of the drug on psychomotor functions is not marked. The drug does not affect the ability to manage transport.

Storage conditions

Store at a temperature not higher than 30 ° C.

Keep out of reach of children.

 

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