CREON 10,000 CAPSULES

/Kreon 10000

Active ingredient

Creon 10,000 - capsules: 1 caps. contains Pancreatin 150 mg, amylase 8000 U of EF, lipase 10,000 U of EF, protease 600 U of UF, excipients: macrogol; liquid paraffin; methyl hydroxypropyl cellulose phthalate; Dimethicone 1000; dibutyl phthalate

capsule shell: iron oxide red (E172); ferric oxide black (E172); iron oxide yellow (E172); titanium dioxide (E171); gelatin; in packing of 20, 50 and 100 pieces.

Mechanism of action

Creon 10000 has a replenishing pancreatic enzyme action.

Indications and usage

Replacement therapy for exocrine pancreatic insufficiency in cystic fibrosis, chronic pancreatitis, pancreatectomy, pancreatic cancer, ductal obstruction (pancreatic duct or common bile duct) due to neoplasm, Shvakhman-Diamond syndrome, in old age;

symptomatic therapy of disorders of the digestive processes during partial resection of the stomach (Billroth-I / II), total gastrectomy; after cholecystectomy, with duodeno- and gastrostasis, biliary obstruction, cholestatic hepatitis, liver cirrhosis, pathology of the terminal part of the small intestine, excessive bacterial growth in the small intestine.

Contraindications

Increased individual sensitivity to the components of Creon 10,000;

acute pancreatitis;

exacerbation of chronic pancreatitis.

Pregnancy and Breastfeeding

Due to the lack of sufficient data on the safety of pancreatic enzymes in women during pregnancy and lactation, Creon 10,000 should be prescribed to pregnant women and breastfeeding mothers only if the expected benefit to the mother outweighs the possible risk to the fetus or child.

Adverse reactions

Allergic reactions, rarely - diarrhea, constipation, stomach discomfort, nausea.

Dosage and administration

Creon 10,000 is taken orally. The dose is selected individually depending on the severity of the disease and the composition of the diet. It is recommended to take 1/3 or 1/2 of the single dose at the beginning of the meal, the rest - during the meal.

In cystic fibrosis, the dose depends on body weight and at the beginning of treatment in children younger than 4 years old - 1000 lipase U / kg for each meal, older than 4 years - 500 lipase U / kg during the meal. The dose depends on the severity of symptoms of the disease, the results of monitoring steatorrhea and maintaining good nutritional status. In most patients, the dose should not exceed 10,000 IU / kg / day.

In other conditions, accompanied by exocrine pancreatic insufficiency, the dose is determined taking into account the individual characteristics of the patient (degree of insufficiency of the digestive system, fat content in food). The dose with the main meal (breakfast, lunch and dinner) is 20000-75000 U of EF lipase, while taking a snack - 5000-25000 U of EF lipase.

The usual initial dosage of Creon is 10,000-25,000 U of EF lipase with the main meal. To reduce steatorrhea and maintain the optimal condition of the patient may increase the dose. According to the usual clinical practice, the patient should receive at least 20,000-50000 U of EF lipase with food.

Storage conditions

In a dry place, at a temperature not higher than 20 ° C. Shelf life - 2 years.