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Clinico-pharmacological group


Pharmacotherapeutic group

Decongestant - alpha adrenomimetic



International non-proprietary name


Dosage Form

Nasal drops


Composition per 1 ml:

0,05 %

0,1 %

Active substance:

Xylometazoline hydrochloride

0.5 mg

1.0 mg


Benzalkonium chloride

0.1 mg

0.1 mg

Sodium chloride

5.0 mg

5.0 mg

Disodium edetat
(ethylenediaminetetraacetic acid disodium salt [Trilon B])

0.5 mg

0.5 mg

Sodium dihydrophosphate
dihydrate (sodium phosphate monosubstituted two-water)

6.0 mg

6.0 mg

Sodium hydrophosphate dodecahydrate
(sodium phosphate disubstituted twelve-tsiativodny)

3.5 mg

3.5 mg

Eucalyptus Leaf Oil
(Eucalyptus oil)

0.85 mg

0.85 mg

Water for injections

up to 1 ml

up to 1 ml

Pharmacological properties

Vasoconstrictor drug for local use in ENT practice. Xylometazoline is an alpha adrenergic mimic, causes constriction of the blood vessels of the nasal mucosa, eliminating its swelling and hyperemia, restores the nasal passability, and quickly facilitates nasal breathing. The effect of the drug occurs within a few minutes after its use and lasts up to 10 hours.


When applied topically, the drug is practically not absorbed, therefore its concentration in the blood plasma is very low (it is not determined by modern analytical methods).

Indications for use

- acute rhinitis (including against the background of acute respiratory diseases and allergic rhinitis);
- sinusitis;
- otitis media (as part of combination therapy to reduce swelling of the mucous membrane of the nasopharynx);
- preparing the patient for rhinoscopy.


- arterial hypertension;
- tachycardia;
- pronounced atherosclerosis;
- glaucoma;
- atrophic rhinitis;
- hyperthyroidism;
- Surgery on the meninges (in history);
- pregnancy;
- children's age up to 6 years (for a 0.1% solution);
- children's age up to 2 years (for 0.05% solution);
- Hypersensitivity to xylometazoline.
Do not use in the treatment of monoamine oxidase inhibitors (MAO) and tricyclic antidepressants.

Use during pregnancy

The drug is contraindicated for use in pregnancy.
During breastfeeding, the drug should be used with caution.

Dosage and administration

Nasal drops of 0.05%, 0.1%.
Adults and children over 6 years old are instilled with 2-3 drops of a 0.1% solution in each nasal passage 3-4 times a day.
Children from 2 to 6 years old instilled with a 0.05% solution, 1-2 drops in each nasal passage - 1-2 times a day. Do not use more than 3 times a day.
The duration of treatment is no more than 3-5 days (without a break).
Before using the drug, unscrew the cap of the vial and instill into the nose by gently pressing the bottom of the vial.

Side effect

Local reactions: with frequent and / or prolonged use - irritation and / or dryness of the mucous membrane of the nasopharynx, burning, paresthesia, sneezing, hypersecretion; rarely - swelling of the nasal mucosa.
Systemic reactions: vomiting, headache, palpitations, increased blood pressure, insomnia, blurred vision, depression (with prolonged use of high doses).


Symptoms: increased dose-related side effects.
Treatment: conduct symptomatic therapy.

Use with other drugs

It is possible to enhance the systemic action with the simultaneous use of monoamine oxidase inhibitors and tricyclic antidepressants.

special instructions

Before use, you must clean the nasal passages.
Do not use for more than 7 days.

Release form

Nasal drops of 0.05%, 0.1%.
On 5 ml or 10 ml in bottles with the nozzle-batcher and the cover screwed from plastic or in bottles-droppers polymeric with the cover screwed on and a dropper a stopper.
Each bottle with the instruction for application is placed in a pack from a cardboard.

Storage conditions

In a dry, dark place, at a temperature not higher than 25 ° C. Keep out of reach of children.

Shelf life 5 years. Do not use beyond the expiration date printed on the package.

Pharmacy sales terms over the counter

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