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COSMETIC BRANDS
AZATHIOPRINE PILLS 50MG
AZATHIOPRINE PILLS 50MG - 50 tabs
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Active ingredient and dosage form
1 pill contains 50 mg of azathioprine.
50 pcs. packaged.
Mechanism of action
Azathioprine is an immunosuppressive agent. Suppresses tissue incompatibility.
Indications and usage
Prevention of graft rejection (as part of combination therapy). Rheumatoid arthritis of severe course, systemic lupus erythematosus, dermatomyositis, periarteritis nodosa, juvenile vulvaris, idiopathic thrombocytopenic purpura, acquired hemolytic anemia, pyoderma gangrenos, chronic hepatitis.
Dosage and administration
Set individually, taking into account the nosological form and severity of the disease, the dosage of simultaneously prescribed drugs, hematological tolerance.
To prevent graft rejection, it is prescribed in a loading dose of 5 mg / kg / day in 2–3 doses over a period of 1–2 months; then switch to a maintenance dose of 1 to 4 mg / kg / day for several years. In other cases, the daily dose is 1-2.5 mg / kg. The treatment is long.
Adverse reactions
Hemic and lymphatic: myelodepression (leukopenia, thrombocytopenia, anemia); possible development of secondary infections, megaloblastic erythropoiesis and macrocytosis; in rare cases - hemolytic anemia.
Gastrointestinal: nausea, vomiting, anorexia, cholestatic hepatitis are possible; in recipients of transplants, pancreatitis, erosive-ulcerative lesions and bleeding from the gastrointestinal tract, necrosis and intestinal perforation were noted.
Allergic reactions: skin rash, arthralgia, myalgia, drug fever are possible.
Other: in rare cases - acute renal failure, acute pulmonary diseases, meningeal reactions.
Contraindications
Pregnancy, hypersensitivity to azathioprine and / or mercaptopurine.
Azathioprine is contraindicated for use in pregnancy. During the period of treatment, women of childbearing age should use reliable methods of contraception.
If necessary, use during lactation should stop breastfeeding.
AT experimental studies The teratogenic, embryotoxic and carcinogenic effects of azathioprine have been established.
During the first 8 weeks of treatment, weekly monitoring of the pattern of peripheral blood is shown, and subsequently, 1-2 times a month, as well as periodic monitoring of the activity of hepatic transaminases, ALP and bilirubin level.
For violations of the kidney and / or liver, as well as the simultaneous use of Allopurinol azathioprine should be used in lower doses.
Drug Interactions
With simultaneous use with co-trimoxazole, the myelotoxic effect of azathioprine may be enhanced. Cases of the development of severe leukopenia with simultaneous use with ACE inhibitors are described.