MEMANTINE PILLS 10MG

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MEMANTINE PILLS 10MG - 84 tabs

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INN: memantine

Pharmacotherapeutic group:

dementia treatment

Indications for use

Dementia of Alzheimer's type of moderate and severe.

Contraindications

Hypersensitivity to memantine or other components of the drug; lactose intolerance, lactase deficiency, glucose-galactose malabsorption; severe renal failure; severe liver failure; pregnancy, breastfeeding period; children and adolescents up to 18 years.

Carefully

With caution prescribed to patients with thyrotoxicosis, epilepsy, convulsions (in history); simultaneous use of NMDA receptor antagonists (amantadine, ketamine, dextromethorphan); the presence of factors that increase the pH of urine (abrupt change of diet, for example, the transition to vegetarianism, abundant intake of alkaline gastric buffer solutions); severe urinary tract infections (caused by Proteus bacteria); myocardial infarction (history), heart failure III-IV functional class (according to the NYHA classification), uncontrolled arterial hypertension; renal failure; liver failure.

Use during pregnancy and during breastfeeding

The drug Memantine is contraindicated for use during pregnancy and during breastfeeding

Dosage and administration

The drug should be taken orally, once a day and always at the same time, regardless of the meal.
Assign as follows:
Week 1 (days 1-7): 5 mg per day (½ pills of 10 mg) for 7 days.
Week 2 (days 8-14): 10 mg per day (1 pill 10 mg) for 7 days.
Week 3 (days 15-21): 15 mg per day (1½ pills of 10 mg) for 7 days.
Starting from the 4th week - 20 mg (1 pill of 20 mg or 2 pills of 10 mg) per day.
The maximum daily dose is 20 mg per day.
The recommended maintenance dose is 20 mg per day.
The duration of treatment is determined by the severity of the patient's response to therapy and the tolerance of the drug.
Special patient groups
Patients older than 65 years, patients with mild renal dysfunction (creatinine clearance 50-80 ml / min), patients with mild or moderately impaired liver function (class A and B on the Child-Pugh scale) do not need dose adjustment.
Patients with impaired renal function
For patients with moderate renal insufficiency (creatinine clearance 30-49 ml / min), the daily dose is 10 mg per day. In the future, with good tolerability of the drug for at least 7 days of treatment, the dose can be increased to 20 mg per day according to the standard regimen.

Side effect

The incidence of side effects is classified according to clinical manifestations and frequency of occurrence: very often (≥ 10%), often (≥ 1%, <10%), infrequently (≥ 0.1%, <1%), rarely (≥ 0.01 %, <0.1%), very rarely (<0.01%, including individual reports), the frequency has not been established (currently there are no data on the prevalence of side effects).
Infection: infrequently - fungal infections.
Violations of the blood and lymphatic system: frequency not established - agranulocytosis, leukopenia (including neutropenia), pancytopenia, thrombocytopenia, thrombocytopenic purpura.
Immune system disorders: often - hypersensitivity to the drug.
Psychological: infrequently - confusion, hallucinations (mainly observed in patients with severe Alzheimer's disease); frequency not established - psychotic reactions.
Nervous system disorders: often - headache, dizziness, drowsiness, imbalance; infrequently - gait disturbance; very rarely - seizures.
Violations of the cardiovascular system: often - arterial hypertension; infrequently - heart failure, venous thrombosis / thromboembolism. Respiratory system disorders: often - shortness of breath.
Disorders of the digestive system: often - constipation; infrequently - vomiting, frequency not established - pancreatitis.
Disorders of the liver and biliary tract: often - elevated liver function tests; frequency not set - hepatitis.
Violations of the skin and subcutaneous tissues: Frequency not established - Stevens-Johnson syndrome.
Kidney and urinary tract disorders: frequency not established - acute renal failure.
Other: infrequently - fatigue.
In Alzheimer's disease, patients may experience depression, suicidal thoughts and attempted suicide.In clinical practice, these effects have been reported in patients taking memantine.

Storage conditions

In the dark place at a temperature of no higher than 30 ° C.
Keep out of the reach of children.

Vacation conditions

On prescription.

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