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BRAL PILLS 500MG - 100tabs



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Composition and release form

1 pill contains metamizol sodium 500 mg, pitofenone hydrochloride 5 mg and fenpiveriniya bromide 0.1 mg; in a blister strip packaging 10 pcs., in a box of 10 packs.

pharmachologic effect

Pharmacological action - anti-inflammatory, antipyretic, analgesic.

Metamizole (a derivative of pyrazolone) has an analgesic, antipyretic and weak anti-inflammatory effect, pitofenone has a direct myotropic effect on smooth muscle, causing it to relax, fenpiverine - a cholinolytic effect and, therefore, also a relaxing effect on smooth muscle. Relieves pain, eliminates smooth muscle spasm, reduces fever.

Indications drug took

Pain syndrome of weak or moderate severity with smooth muscle spasms (renal and biliary colic, intestinal spasm, dysmenorrhea, etc.), neuralgia, arthralgia, myalgia, pain after diagnostic and surgical interventions, fever with colds and infectious and inflammatory diseases.


Hypersensitivity, marked disorders of the liver and kidneys, congenital deficiency of glucose-6-phosphate dehydrogenase, tachyarrhythmia, collaptoid state,impaired blood formation, angle-closure glaucoma, intestinal obstruction, megacolon, prostate hypertrophy with a tendency to accumulation of residual urine, pregnancy (I trimester and the last 6 weeks), breastfeeding, children (up to 6 years).

Use during pregnancy and lactation

Contraindicated in the first trimester and in the last 6 weeks of pregnancy. At the time of treatment should stop breastfeeding.

Side effects

From the nervous system and sensory organs: dizziness, in isolated cases - headache.

Since the cardiovascular system and blood (hematopoiesis, hemostasis): lowering blood pressure, tachycardia, thrombocytopenia, leukopenia, agranulocytosis.

Allergic reactions: skin rash, itching, very rarely - anaphylactic shock, with a tendency to bronchospasm may provoke an attack.

Other: dry mouth, burning sensation in the epigastric region (in isolated cases), cyanosis.


Tricyclic antidepressants, oral contraceptives, Allopurinol, violate the metabolism in the liver and increase toxicity. The effect is enhanced by sedatives and tranquilizers, weaken - barbiturates, phenylbutazone and other inducers of liver microsomal enzymes. Dr. non-narcotic analgesics potentiate the side effects, and cyclosporine reduces the plasma level.

Dosage and administration

Inside, preferably after a meal.

Adults: and children over 15 years old for 1-2 tables. 2-3 times a day, the maximum daily dose of 6 tablets.

Children: only on doctor's prescription: 6-8 years old 1/2 table., 9-12 years old - 3/4 table., 13-15 years old - 1 table. 2-3 times a day. Reception duration no more than 5 days.

Precautionary measures

With caution used in patients with impaired liver or kidney, prone to hypotension and bronchospasm, with increased sensitivity to NSAIDs or other non-narcotic analgesics.

With long-term use is necessary to control the pattern of peripheral blood and liver function.

special instructions

Metamizole metabolites may stain urine red.

Storage conditions of the drug I took

In a dry, dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

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