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1 pill contains:
Active substances: metamizole sodium 500 mg, caffeine 50 mg, thiamine hydrochloride 38.75 mg; Excipients: microcrystalline cellulose 45.75 mg, wheat starch 11.00 mg, gelatin 4.00 mg, colloidal silicon dioxide 2.50 mg, talc 12.00 mg, Magnesium stearate 6.00 mg.

round flat pills from white to almost white color, with a double-sided facet and a risky one side.



The combined drug has analgesic, antipyretic and anti-inflammatory effects.

Metamizole Sodium
 is a derivative of pyrazolone and has analgesic, antipyretic and weak anti-inflammatory action, the mechanism of which is associated with the inhibition of prostaglandin synthesis by inhibiting cyclooxygenase.

Caffeine - has a stimulating effect on the central nervous system (CNS), mainly on the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness, fatigue. Caffeine increases the permeability of histohematogenous barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect.

Thiamine (vitamin B,) is involved in metabolism, and contributes to the improvement of neuro-reflex

Indications and usage

Moderately or mild pain, of various genesis: headache (including migraine), toothache, neuralgia, muscle pain (myalgia), joint pain (arthralgia), radicular syndrome, menstrual pain (algomenorrhea).
Feverish syndrome with colds and other infectious and inflammatory diseases (with the established diagnosis).


Hypersensitivity to the drug.
Hypersensitivity to other pyrazolone derivatives - phenylbutazone.
Severe hepatic and / or renal failure.
Deficiency of glucose-6-phosphate dehydrogenase (congenital insufficiency syndrome of the enzyme
gozo-6-phosphate dehydrogenase).
Diseases of the blood system.
Uncontrolled arterial hypertension. Pronounced atherosclerosis. Increased intraocular pressure. Pregnancy and breastfeeding period. Children's age (up to 12 years).
With care - abnormal liver function and / or kidneys.
Dosage and administration
Inside after eating 1 pill 2-3 times in the morning. The maximum single dose for adults and adolescents from 16 years old - 2 tablets, the maximum daily dose - 6 pills not more than 1-2 days.
Children aged 12 to 16 years old - in half or one pill 2-3 times a day, the maximum daily dose is 4 tablets.
The duration of treatment is no more than 5 days when prescribed as an anesthetic and 3 days as an antipyretic.
If the symptoms of the disease continue or worsen, you should consult a doctor. Increasing the daily dose of the drug or the duration of treatment is possible only under medical supervision.

Adverse reactions

On the part of the gastrointestinal tract: loss of appetite, nausea, vomiting, cholestasis, jaundice.
From the side of blood-forming organs: thrombocytopenia, leukopenia, agranulocytosis, hemolytic
anemia, purpura.
On the part of the central nervous system: insomnia, dizziness, irritability.
Since the cardiovascular system: feeling of heartbeat, heart rhythm disturbances. Allergic reactions: skin rash, itching, redness, angioedema, anaphylactic shock; bronchospasm.
All side effects should be reported to your doctor.


Symptoms: nausea and vomiting sometimes with blood, pain in the stomach, mental and motor agitation, tachycardia, cardiac rhythm disturbances, reduction or increase in diuresis, convulsions, anxiety, confusion, delirium, dehydration, hyperthermia, headache, increased tactile or painful sensitivity are possible tremor or muscle twitching; tinnitus, epileptic seizures (in acute overdose - tonic-clonic).
Treatment: seek medical attention immediately. The victim should make a gastric lavage, appoint adsorbents (for example, activated carbon), laxative drugs. If necessary, symptomatic treatment is carried out (for hemorrhagic gastritis - the introduction of antacid drugs and gastric lavage with ice-cold 0.9% sodium chloride solution; maintaining ventilation and oxygenation; with epileptic seizures - intravenous diazepam, phenobarbital or phenytoin; maintaining fluid and salt balance).

Drug interactions

The simultaneous use of metamizole sodium (aspirin) with other non-narcotic analgesics, nonsteroidal anti-inflammatory drugs can lead to mutual enhancement of toxic effects.
Tricyclic antidepressants, oral contraceptives, Allopurinol violate the metabolism of metamizole sodium in the liver and increase its toxicity.
Barbiturates, phenylbutazone (butadiene) and other inducers of liver microsomal enzymes weaken the effect of metamizole sodium. The simultaneous use of metamizole sodium with cyclosporine reduces the concentration of the latter in the blood.
Sedatives and tranquilizers enhance the analgesic effect of metamizole sodium. special instructions
Excessive consumption of caffeine-containing products (tea, coffee) during treatment may cause symptoms of overdose.
With caution and under medical supervision used in patients with impaired liver or kidney function.
The simultaneous use of the drug with alcohol-containing beverages is not recommended.
Patients with atopic asthma, hay fever, have an increased risk of developing
hypersensitivity reactions.
Influence on ability to drive vehicles and work with mechanisms
Care must be taken when driving and working with mechanisms that require increased concentration and psychomotor speed, since dizziness may develop when taking the drug.

Dosage form

Pills. 10 pills in a blister of three-layer PVC / PVDH / PVC film or two-layer PVC / PVD film and aluminum foil.
1 or 2 blisters along with instructions for use in a carton box.

Storage conditions

In a dry, dark place, at a temperature not higher than 25 ° C. Keep out of the reach of children!

Over the counter.

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