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Symptomatic therapy of painful and inflammatory processes of various origins, including:

inflammatory and degenerative diseases of the musculoskeletal system:

- rheumatoid arthritis;

- seronegative arthritis (ankylosing spondylitis / Bechterew's disease /, psoriatic arthritis, reactive arthritis / Reiter's syndrome /);

- gout, pseudogout;

- osteoarthritis.

pain syndrome:

- headache;

- tendonitis, bursitis, myalgia, neuralgia, sciatica;

- post-traumatic and postoperative pain syndrome;

- Algomenorrhea;

- pain syndrome in oncological diseases.

Dosage and administration

For adults the drug is prescribed in 1-2 caps. 2-3 times / day, or 1 tab. 2 times / day, or 1 tab. prolonged action 1 time / day. Capsules and pills should be taken during or immediately after a meal, without chewing, drinking plenty of water or milk (the volume of the liquid is at least 100 ml).

Oral forms can be combined with the use of rectal suppositories or Ketonal dosage forms for external use (cream, gel).

The maximum daily dose (including the use of various dosage forms) is 200 mg.

Adverse effects

The incidence of adverse reactions: very common (> 10%), common (> 1%, but <10%), uncommon (> 0.1%, but <1%), rare (> 0.01%, but <0.1%), very rare (<0.01%).

Gastrointestinal: common - dyspepsia (nausea, flatulence, diarrhea or constipation, vomiting, decreased or increased appetite), abdominal pain, stomatitis, dry mouth; not common (with long-term use in large doses - ulceration of the gastrointestinal mucosa, impaired liver function); rare - perforation of gastrointestinal organs, exacerbation of Crohn's disease, melena, bleeding from the gastrointestinal tract, transient increase in the level of liver enzymes.

Nervous system: common - headache, dizziness, drowsiness, fatigue, nervousness, nightmares; rare - migraine, peripheral neuropathy; very rare - hallucinations, disorientation, speech disorder.

From the senses: rare - tinnitus, change in taste, blurred vision, conjunctivitis.

Since the cardiovascular system: not common - tachycardia, arterial hypertension, peripheral edema.

From the hemopoietic system: decreased platelet aggregation; rare - anemia, thrombocytopenia, agranulocytosis, purpura.

From the urinary system: rare - impaired renal function, interstitial nephritis, nephrotic syndrome, hematuria (with long-term use of NSAIDs and diuretics).

Allergic reactions: common - itching, urticaria; not common - rhinitis, shortness of breath, bronchospasm, angioedema, anaphylactoid reactions.

Other: rare - hemoptysis, metrorrhagia.


- bronchial asthma, rhinitis, urticaria in history, caused by the intake of Acetylsalicylic acid or other NSAIDs;

- peptic ulcer of the stomach and duodenum in the acute phase;

- UC, Crohn's disease;

- hemophilia and other bleeding disorders;

- severe liver failure;

- severe renal failure;

- progressive kidney disease;

- uncompensated heart failure;

- The postoperative period after coronary artery bypass surgery;

- gastrointestinal, cerebrovascular and other bleeding (or suspected bleeding);

- chronic dyspepsia;

- children's age up to 15 years;

- III trimester of pregnancy;

- lactation period (breastfeeding);

- hypersensitivity to Ketoprofen or other components of the drug, as well as salicylates or other NSAIDs.

WITH caution It should be prescribed for a history of peptic ulcer disease, a history of bronchial asthma, clinically significant cardiovascular, cerebrovascular diseases, diseases of the peripheral arteries, dyslipidemias, hepatic failure, hyperbilirubinemia, alcoholic cirrhosis of the liver, renal failure, chronic heart failure, and in hysterism, and if you need to be hardened., dehydration, diabetes, anamnestic data on the development of ulcerative lesions of the gastrointestinal tract, smoking,concomitant therapy with anticoagulants (for example, warfarin), antiplatelet agents (for example, acetylsalicylic acid), oral GCS (for example, prednisolone), selective serotonin reuptake inhibitors (for example, citalopram, sertralin).

Use during pregnancy and lactation

The use of ketoprofen in the third trimester of pregnancy is contraindicated. In the first and second trimesters of pregnancy, prescribing is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.

When taking the drug during lactation should decide on the termination of breastfeeding.

Application for violations of the liver

Contraindicated in severe renal impairment.

Application for violations of kidney function

Contraindicated in severe renal impairment.

Use in children

Contraindications: children up to 15 years.

Use in elderly patients

With prolonged use of NSAIDs, it is necessary to monitor the state of the blood, as well as the function of the kidneys and liver, especially in elderly patients (over 65).

Special notes

Ketonal® you can drink milk or take it with antacid drugs in order to reduce the frequency of gastrointestinal disorders (milk and antacids do not affect the absorption of ketoprofen).

With long-term use of NSAIDs, it is necessary to monitor the state of the blood, as well as the function of the liver and kidneys, especially in elderly patients.

Care must be taken and more often to control blood pressure when using ketoprofen for the treatment of patients with hypertension, cardiovascular diseases that lead to fluid retention.

Like other NSAIDs, ketoprofen can mask the symptoms of infectious diseases.

Influence on ability to drive motor transport and control mechanisms

There are no data on the negative effect of Ketonal in recommended doses on the ability to drive a car or work with mechanisms. However, patients who notice non-standard effects while taking the drug Ketonal®Care should be taken when practicing potentially hazardous activities that require increased concentration and psychomotor reactions.


Symptoms: nausea, vomiting, abdominal pain, vomiting with blood, melena, impaired consciousness, respiratory depression, convulsions, impaired renal function, renal failure.

Treatment: gastric lavage, the appointment of activated charcoal, spend symptomatic therapy. The use of histamine H blockers is shown.2-receptors, proton pump inhibitors, prostaglandin inhibitors. There is no specific antidote.

Drug interaction

Ketoprofen reduces the effect of diuretics, antihypertensive agents.

Enhances the action of oral hypoglycemic drugs.

Enhances the effect of some anticonvulsants (for example, phenytoin).

With simultaneous use with other NSAIDs, salicylates, corticosteroids and ethanol increases the risk of Gastrointestinal bleeding.

When used simultaneously with anticoagulants, thrombolytics, antiplatelet agents, the risk of bleeding increases.

The risk of developing impaired renal function is increased when taken simultaneously with diuretics or ACE inhibitors.

With simultaneous use increases the concentration of cardiac glycosides, slow Calcium channel blockers, lithium preparations, cyclosporine, Methotrexate.

Ketoprofen may decrease the effectiveness of mifepristone. Acceptance of NSAIDs should begin no earlier than 8-12 days after the abolition of mifepristone.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not higher than 25 ° C.

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