PAPAVERINE HYDROCHLORIDE CANDLE 20MG
PAPAVERINE HYDROCHLORIDE CANDLE 20MG - 10pcs
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1 suppository contains:
active substance - 0.02 papaverine hydrochloride;
Excipients: solid fat, witepsol.
Mechanism of action
Papaverine - antispasmodic. Reduces the tone of smooth muscles and has in connection with this vasodilator and spasmolytic effect. It is an inhibitor of the enzyme phosphodiesterase and causes intracellular accumulation of cyclic 3,5 - adenosine monophosphate and a decrease in Calcium content, which leads to a violation of smooth muscle contractility and their relaxation. The action of papaverine hydrochloride on the central nervous system is weakly expressed, only in large doses reduces the excitability of the heart muscle and slows down intracardiac conduction.
Indications and usage
Spasm of peripheral vessels, brain vessels. Angina pectoris (as part of complex therapy), bronchospasm, spasm of the smooth muscles of the abdominal organs (pylorospasm, spastic colitis, cholecystitis, bouts of gallstone disease), spasm of the urinary tract, renal colic.
Hypersensitivity to the drug, atrioventricular (AV) blockade, glaucoma, severe liver failure, advanced age (risk of developing hypertension), children under 1 year of age, prostatic hyperplasia, supraventricular tachycardia, shock states.
Dosage and administration
Rectal, for adults, 0.02 - 0.04 g (1-2 candles) 2-3 times a day.
In a dry, dark place at a temperature of from 12 to 15 ° C. In the reach of children.