KETONAL CANDLES 100 MG
KETONAL CANDLES 100 MG - 12pcs
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Active ingredient and dosage form
suppositories white, smooth, homogeneous.
1 suppository contains Ketoprofen 100 mg;
Excipients: solid fat, migliol.
12 pcs. packaged.
capsules opaque, with a white case and a blue lid.
1 capsule contains ketoprofen 50 mg;
Excipients: vegetable oil, hydrogenated soybean oil, beeswax, gelatin, glycerol, sorbitol, titanium dioxide, sodium ethyl p-hydroxybenzoate, sodium propyl-p-hydroxybenzoate.
25 pcs. in dark glass bottles, 1 bottle in a carton box.
Ketonal pills forte, coated light blue, round, biconvex.
1 pill contains ketoprofena 100 mg;
Excipients: magnesium stearate, colloidal silicon dioxide, povidone, starch, purified talcum, lactose sieve 200, hydroxypropylmethylcellulose, polyethylene glycol 400, indigotin blue dye (E132), titanium dioxide, carnauba wax.
20 pcs. in dark glass bottles, 1 bottle in a carton box.
tablet retard white, round, biconvex.
1 pill retard contains ketoprofen 150 mg;
Excipients:magnesium stearate, colloidal silicon dioxide, povidone, microcrystalline cellulose, hydroxypropylmethylcellulose.
20 pcs. in dark glass bottles, 1 bottle in a carton box.
Ketonal injection colorless or slightly yellowish, transparent.
1 ml contains ketoprofen 50 mg (1 ampoule - 100 mg);
Excipients: propylene glycol, ethanol, benzyl alcohol, sodium hydroxide, water d / u.
2 ml in dark glass ampoules, 10 or 50 ampoules in a carton box.
Ketonal cream 5% white or almost white, homogeneous.
1 g of cream contains ketoprofen 50 mg;
Excipients: methylhydroxybenzoate, propylhydroxybenzoate, propylene glycol, isopropyl myristate, white petrolatum, polyethylene glycol-45-dodecyl glycol (Elfakos), sorbitan ether of fatty acids (Arlacel), Magnesium sulfate, purified water.
30 g in aluminum tubes, 1 tube in a carton box.
Mechanism of action
- NSAID, a derivative of propionic acid. It has an analgesic, anti-inflammatory and antipyretic effect.The mechanism of action is associated with inhibition of prostaglandin synthesis at the level of cyclooxygenase. In addition, ketoprofen inhibits lipo-oxygenase, has anti-bradykinin activity, stabilizes lysosomal membranes, and causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis.
The pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system).
Indications and usage
For system use
- symptomatic therapy of painful inflammatory processes of various genesis (including postoperative and post-traumatic pain, ischialgia, myalgia, sciatica, bruises and muscle strain, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute gout, tenosynovitis, bursitis); symptomatic treatment of acute pain syndrome in inflammatory diseases of the musculoskeletal system (only for IM administration);
For external use
- rheumatoid arthritis, ankylosing spondylitis, osteoarthritis of various localization, periarthritis; sciatica, myalgia, radiculitis; synovitis, tendonitis, tendosynovitis, bursitis; bruises, sprains, sprains; phlebitis, thrombophlebitis of superficial veins, lymphangitis.
Diseases of the gastrointestinal tract in the acute phase; severe liver dysfunction; severe renal impairment; blood disorders (leukopenia, thrombocytopenia, disorders of the blood coagulation system); III trimester of pregnancy; lactation (breastfeeding); children up to 15 years; hemorrhoids and proctitis (for suppositories); hypersensitivity to ketoprofen, Acetylsalicylic acid, or other NSAIDs (history of bronchospasm, urticaria, and rhinitis, caused by taking acetylsalicylic acid).
Dosage and administration
For adults the drug is prescribed 1-2 capsules 2-3 times / day; or 1 tab. Forte 2-3 times / day; or 1 tab. retard 1-2 times / day.
Capsules and pills should be taken during or immediately after a meal, without chewing, drinking plenty of water.
Suppositories prescribe 1 pc. 1-2 times / day. Suppositories are inserted deep into the rectum.
The maximum daily dose is 300 mg.
For the relief of acute pain the drug is administered in / m 2 ml 1-2 times / day. The duration of parenteral therapy is usually several days. After achieving the desired effect, the drug is prescribed in the form of capsules, pills or suppositories.
The cream is applied with a thin layer on the skin over the lesion 2-3 times / day, slightly rubbing. Duration of treatment - 14 days or more (after consulting a doctor).
Gastrointestinal: nausea, flatulence, abdominal pain, diarrhea, vomiting; rarely - bleeding from the gastrointestinal tract.
From the side of the central nervous system: rarely - headache, dizziness, drowsiness, tinnitus.
Allergic reactions: rarely - itching, urticaria.
Local reactions: when using suppositories - a burning sensation, tenesmus, loose stools.
Other: transient dysuria, asthenia.
With caution, the drug is prescribed for violations of the liver or kidneys, with a history of gastrointestinal diseases, bronchial asthma, rhinitis, urticaria, polyps of the nasal mucosa, heart failure, in elderly patients.
Care should be taken with the simultaneous use of Ketonal with acetylsalicylic acid or other NSAIDs, lithium preparations, antihypertensive drugs, diuretics, Methotrexate, antidiabetic drugs.
When applying Ketonala in the form of a cream, avoid contact with the damaged surface, open wounds, eyes and other mucous membranes.
During the period of treatment is prohibited to drink alcohol.
Influence on ability to drive motor transport and control mechanisms
When using the drug, caution should be exercised to persons whose activities require quick psychomotor reactions (driving a car, working with mechanisms).
Since Ketotifen is largely bound to plasma proteins, the doses of anticoagulants, diphenylhydantoin or sulfur-containing drugs used simultaneously with Ketonal should be reduced.