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It has an analgesic, anti-inflammatory and antipyretic effect.

The mechanism of action is associated with inhibition of prostaglandin synthesis at the level of cyclooxygenase.

In addition, Ketoprofen inhibits lipo-oxygenase, has anti-bradykinin activity, stabilizes lysosomal membranes, and causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis.

  • symptomatic therapy of painful inflammatory processes of various origins (including postoperative and post-traumatic pain, ischialgia, myalgia, sciatica, bruises and muscle strain, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute attack of gout, tenosinovitis, bursitis);
  • symptomatic treatment of acute pain syndrome in inflammatory diseases of the musculoskeletal system (only for IM administration)


  • diseases of the gastrointestinal tract in the acute phase;
  • severe liver dysfunction;
  • severe renal impairment;
  • blood disorders (leukopenia, thrombocytopenia, disorders of the blood coagulation system); I
  • children up to 15 years;
  • hemorrhoids and proctitis (for suppositories);
  • hypersensitivity to ketoprofen, Acetylsalicylic acid, or other NSAIDs (history of bronchospasm, urticaria, and rhinitis, caused by taking acetylsalicylic acid).

Pregnanacy and breastfeeding

The use of Ketonala in the third trimester of pregnancy is contraindicated.

The use of Ketonal in the I and II trimesters of pregnancy is possible only in the case when the potential benefit to the mother exceeds the risk to the fetus.

If necessary, use Ketonala during lactation should decide on the termination of breastfeeding.

Special notes

With prolonged use of Ketonal, as well as other NSAIDs, regular monitoring of hematological parameters, indicators of liver function and kidney function, especially in elderly patients, is required.

Ketoprofen should be carefully prescribed to patients with hypertension and heart disease, accompanied by fluid retention in the body, it is recommended to monitor blood pressure.

Ketonal can mask the symptoms of infectious diseases.

In connection with the photosensitivity of the drug vials with an infusion solution should be wrapped in dark paper or foil.

There are no data on the negative effect of Ketonal in recommended doses on the ability to drive a car and work with machinery. However, when using the drug, care should be taken to persons whose activities require quick psychomotor reactions (driving a car, working with mechanisms).

Active ingredient

1 ml of solution for in / in and in / m introduction contains: Ketoprofen 50 mg.

Excipients: propylene glycol, ethanol, benzyl alcohol, sodium hydroxide, water d / u.

Dosage and administration

The solution is injected in / m or / in.

V / m administered 100 mg 1-2 times / day.

In / in the infusion of ketoprofen carried out only in a hospital.

A short intravenous infusion: 100-200 mg, diluted in 100 ml of a 0.9% solution of sodium chloride, is administered within 0.5-1 hours. It is possible to reintroduce after 8 hours.
Prolonged intravenous infusion: 100–200 mg, diluted in 500 ml of infusion solution (0.9% sodium chloride solution, Ringer’s lactate-containing solution, 5% dextrose solution) are administered within 8 hours. Re-administration after 8 hours is possible.

The maximum daily dose (including the use of various dosage forms) is 200 mg.

Adverse effects

Allergic reactions: common - skin reactions (itching, urticaria); not common - rhinitis, shortness of breath, bronchospasm, angioedema, anaphylactoid reactions.

Digestive system: common - dyspepsia (nausea, diarrhea or constipation, flatulence, vomiting, decreased or increased appetite), abdominal pain, stomatitis, dry mouth, not common (with prolonged use in large doses) - ulceration of the gastrointestinal mucosa, impaired liver function; rare - perforation of the digestive tract, exacerbation of Crohn's disease, melena, Gastrointestinal bleeding.

CNS: common - headache, dizziness, sleep disturbance, fatigue, nervousness, nightmares; rare - migraine, peripheral polyneuropathy; very rare - hallucinations, disorientation and speech disorder.

Sense organs: rare - tinnitus, change in taste, blurred vision, conjunctivitis.

SSS: not common - tachycardia, arterial hypertension, peripheral edema.

Urinary system: rare - impaired renal function, interstitial nephritis, nephrotic syndrome, hematuria (often develop in people who take NSAIDs for a long time and diuretics).

Other: rare - hemoptysis, menometorrhagia.

Laboratory values: ketoprofen reduces platelet aggregation; transient increase in the level of liver enzymes; rare - anemia, thrombocytopenia, agranulocytosis, purpura.

Drug interactions


Symptoms: nausea, vomiting, abdominal pain, vomiting with blood, melena, impaired consciousness, respiratory depression, convulsions, impaired renal function, renal failure.

Treatment: gastric lavage, the appointment of activated charcoal, spend symptomatic therapy.

The use of histamine H 2 receptor blockers, proton pump inhibitors, and prostaglandin inhibitors has been shown. There is no specific antidote.

The drug should be stored at a temperature not higher than 25 ° C

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