ANALGIN-QUININE PILLS

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ANALGIN-QUININE PILLS - 20 tabs

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Active ingredient

Coated tablets: 1 pill contains: 
active substances: metamizole sodium 200 mg, quinine hydrochloride 50 mg;
excipients: wheat starch, polyvinylpyrrolidone K-25, glycerin, Magnesium stearate, talc, micrichel
10 pieces per pack.

Mechanism of action

Analgin-quinine - a combined drug, refers to analgesic non-narcotic drugs.
Metamizole sodium is a derivative of pyrazolone and has analgesic, antipyretic and minor anti-inflammatory action, the mechanism of which is associated with inhibition of prostaglandin synthesis.
Quinine is an alkaloid of the cinchona bark, it has antipyretic effect, reduces the excitability of the heart muscle, increases the contractility of the myometrium, causes a contraction of the spleen capsule, and has a slight suppressive effect on the central nervous system.

Indications and usage

- moderately or weakly expressed pain syndrome (including headache, toothache, migraine, neuralgia, arthralgia, myalgia, root pain, algomenorrhea);
- pain and fever in acute viral and bacterial diseases of the upper respiratory tract, as well as other infectious and inflammatory diseases;
- fever of various genesis. Use as an antipyretic is advisable after the diagnosis of the disease. The need to use the drug is solved in each case, depending on the severity, nature and tolerability of fever.

Contraindications

- pronounced disorders of the liver and kidneys;
- a tendency to bronchospasm;
- genetic absence of glucose-6-phosphate dehydrogenase;
- diseases of the blood system;
- severe myasthenia gravis;
- inflammation of the middle and inner ear;
- atrial fibrillation and flutter;
- the period of pregnancy (quinine can cause a reduction in myometrium) and breastfeeding;
- children's age up to 6 years;
- hypersensitivity to the components of the drug, as well as to other pyrazolone derivatives (butadione, tribuzone, antipyrine, amidopyrine)

Dosage and administration

Analgin-quinine pills are taken orally after a meal, without chewing, usually 1-2 pills 1-3 times a day, depending on the clinical picture. 
The maximum single dose for adults 5 tablets, daily - 12 tablets. 
For children 6-10 years old - one pill 2 times a day, children 10-14 years old - one pill 3-4 times a day.
Reception duration no more than 5 days. The increase in the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Special notes

Carefully Analgin-quinine should be prescribed to patients with impaired liver and kidney function, vision and hearing impairment, with angina pectoris and heart failure.
With a long (more than a week) use of the drug, it is necessary to control the picture of peripheral blood and the functional state of the liver. It is advisable to monitor the ECG. 
Influence on ability to drive motor transport and control mechanisms
During the period of taking the drug should not perform work that requires increased attention and speed of psychomotor reactions.

Adverse reactions

Allergic reactions: skin rash, itching, angioedema; rarely - anaphylactic shock.
Gastrointestinal: nausea, vomiting, epigastric pain.
From the side of the central nervous system: headache, tinnitus and hearing loss, blurred vision, dizziness, fatigue.
Cardiovascular: angina attacks, heart rhythm disorder.
Hemic and lymphatic: with prolonged use - thrombocytopenia, leukopenia, agranulocytosis, hypoprothrombinemia.
Other: renal dysfunction, bronchospasm, fever.

Overdosage

Symptoms: nausea, vomiting, epigastric pain, vestibular disorders, tinnitus, clonic and tonic convulsions, coma, agranulocytosis, aplastic anemia, hemorrhagic diathesis, skin rash, manifestations of cardiotoxic action.
Treatment: gastric lavage, standard detoxifying measures, if necessary - symptomatic therapy. There is no specific antagonist or antidote.

Drug Interactions

The simultaneous use of the drug Analgin-Quinine with other analgesics, antipyretics can lead to increased toxic effects.
With the simultaneous use of quinine with aminoglycoside antibiotics, mutual enhancement of the ototoxic effect can occur.
Quinine may potentiate the effects of neuromuscular blocking agents.
Tricyclic antidepressants, oral contraceptives, Allopurinol violate the metabolism of metamizole sodium in the liver and increase its toxicity.
Chloramphenicol enhances the myelotoxic effect of metamizole sodium.
Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effect of metamizole sodium.
Sedatives and tranquilizers enhance the analgesic effect of metamizole sodium.
The simultaneous use of metamizole sodium with cyclosporine reduces the level of the latter in the blood.

Storage conditions

store in a dry, dark place at a temperature of from 15 ° to 25 ° C.

- 5 years.

Analgin-quinine

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