DERINAT AMPOULES 1.5% 5ML

Trade name of the drug: Derinat®.

International non-proprietary name: Derinat (Derinat).

Dosage Form: Solution for intramuscular injection.

Composition: Active ingredient: sodium deoxyribonucleate 1.5 g. Auxiliary substances: sodium chloride 0.9 g, water for injection - 100 ml

Description: transparent colorless liquid.

Pharmacotherapeutic group: immunomodulatory agent, hematopoietic stimulator, regenerant, reparant.

Pharmacology

The drug activates the processes of cellular and humoral immunity. The immunomodulating effect is caused by stimulation of B-lymphocytes, activation of T-helper cells. Derinat activates nonspecific resistance of the organism, optimizing inflammatory reactions, and the immune response to bacterial, viral and fungal antigens. Stimulates reparative and regenerative processes. Increases the body's resistance to infections, regulates hemopoiesis (helps normalize the number of leukocytes, lymphocytes, granulocytes, phagocytes, platelets). Having a pronounced lymphotropic, Derinat stimulates the drainage-detoxification function of the lymphatic system. Derinat significantly reduces the sensitivity of cells to the damaging effects of chemotherapeutic drugs and radiation therapy. The drug does not possess embryotoxic, teratogenic and carcinogenic effects.

Pharmacokinetics

Suction and distribution

The drug is rapidly absorbed and distributed in organs and tissues with the participation of the endolymphatic transport route. It has a high tropism for the organs of the hematopoietic system, is actively involved in cellular metabolism, integrating into cellular structures. In the phase of intensive delivery of the drug into the blood, there is a redistribution between plasma and blood cells, in parallel with metabolism and excretion. After a single injection, all pharmacokinetic curves describing changes in the concentration of the drug in the organs and tissues studied are characterized by a rapid increase phase and a fast phase reduction in the time interval of 5 to 24 hours. The elimination half-life (T?) With intramuscular administration is 72.3 hours. Derinat is quickly distributed throughout the body, in the course of daily course application cumulates in organs and tissues: maximally: - in the bone marrow, lymph nodes, spleen, thymus; to a lesser extent - in the liver, brain, stomach, small and large intestines. The maximum concentration in the bone marrow is determined after 5 hours after drug administration. The drug overcomes the hemato-encephalic barrier. The maximum concentration of the drug in the brain is achieved after 30 minutes.

Metabolism and excretion.

Derinat is metabolized in the body. Excreted from the body (in the form of metabolites), partially with feces, and, to a greater extent, with urine due to biexponential dependence.

Indications

• radiation damage;
• violation of hematopoiesis;
• myelodepression and resistance to cytostatics in cancer patients, developed on the background of cytostatic and / or radiation therapy (stabilization of hemopoiesis, reduction of cardiovascular and myelotoxicity of chemotherapy);
• stomatitis induced by cytostatic therapy;
• peptic ulcer and 12 duodenal ulcer, erosive gastroduodenitis;
• coronary heart disease;
• obliterating vascular diseases of the lower extremities, chronic ischemic disease of the lower extremities II - III stage;
• trophic ulcers, nonhealing wounds;
• odontogenic sepsis, purulent-septic complications;
• rheumatoid arthritis;
• burn disease;
• preoperative and postoperative periods (in surgical practice);
• endometritis, salpingo-oophoritis, endometriosis, myomas;
• chlamydia, ureaplasmosis, mycoplasmosis;
• prostatitis, benign prostatic hyperplasia;
• chronic obstructive pulmonary disease;
• pulmonary tuberculosis, inflammatory diseases of the respiratory tract.

Contraindications

Individual intolerance.

Pregnanacy and breastfeeding

Consultation with a doctor is required. If necessary, the appointment of the drug during pregnancy should assess the expected benefits to the mother and the potential risk to the fetus. During lactation apply strictly on doctor's prescription.

How to prick Derinat: Dosage and administration

Adults: intramuscularly within 1-2 minutes in 5 ml of 1.5% (75 mg) solution, with an interval of 24-72 hours.

In ischemic heart disease - 10 injections with an interval of 48-72 hours.

In case of peptic ulcer of the stomach and duodenum - 5 injections with an interval of 48 hours.

In case of cancer - 3-10 injections with an interval of 24-72 hours.

In gynecology (endometritis, chlamydia, ureaplasmosis, mycoplasmosis, salpingoophoritis, myomas, endometriosis) - 10 injections with an interval of 24-48 hours.

In andrology (prostatitis, benign prostatic hyperplasia) - 10 injections with an interval of 24-48 hours.

With pulmonary tuberculosis - 10-15 injections with an interval of 24-48 hours.

In acute inflammatory diseases - 3-5 injections with an interval of 24-72 hours.

In chronic inflammatory diseases - 5 injections with an interval of 24 hours, then - 5 injections, with an interval of 72 hours.

When using a 1.5% solution of 2 ml, intramuscular injections should be carried out daily, making recalculations, until a course dose of 375-750 mg is reached.

For children, the drug is administered intramuscularly in the same way as adults. Children under the age of 2 years, the drug is prescribed in a single dose of 7.5 mg (0.5 ml). In children aged 2 to 10 years, a single dose is determined at the rate of 0.5 ml of the drug per year of life.

From the age of 10, a single dose - 5 ml of a 1.5% solution, a course dose - up to 5 injections (15 mg / ml) of the drug.

Adverse Effects

In patients with diabetes mellitus, hypoglycemic effect is noted, which should be considered by controlling blood sugar levels.

Overdosage

Negative effects of overdose have been identified.

Interaction with other drugs

The use of Derinat in the complex therapy allows to increase the effectiveness and shorten the duration of treatment, with a significant reduction in doses of antibiotics and antiviral agents with an increase in the periods of remission.

Derinat increases the effectiveness of antitumor antibiotics anthracycline, cytotoxic drugs.

The drug potentiates the therapeutic effect of basic therapy in gastric ulcer and 12 duodenal ulcer. Derinat reduces iatrogenicity of basic drugs in the treatment of rheumatoid arthritis with the achievement of 50% and 70% improvement in a number of complex indicators of disease activity.

In surgical sepsis, the introduction of Derinat into the complex therapy causes a decrease in the level of intoxication, activation of the immune system, normalization of blood formation, improves the functioning of the organs responsible for the processes of detoxification of the internal environment of the body (lymph nodes, spleen, etc.).

Special notes

The drug can be administered subcutaneously.

Storage conditions

Store in a dark place out of the reach of children, at a temperature of + 4 ° C to + 20 ° C.