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Sodium Hyaluronate

Dosage form


Active ingredient

Active ingredient: hyaluronic acid; 2 ml of solution contain 30 mg of sodium hyaluronic acid. Auxiliary substances: sodium chloride; sodium dihydrophosphate, dihydrate; sodium hydrogen phosphate, dodecahydrate; water for injections.

Mechanism of action

Means used in the pathology of the musculoskeletal system.

Indications and usage

Traumatic and degenerative pathology of the joints. Auxiliary tool for orthopedic surgery.


Individual hypersensitivity to the drug. History of allergy to poultry proteins. Severe abnormal liver function. Intra-articular injections are contraindicated in the case of an existing infection or skin disease in the area of ​​the injection site in order to reduce the potential development of septic arthritis.

Adverse reactions

Reactions at the injection site, including discomfort, pain, swelling, redness, irritation, rashes, nodules, pustules, vesicles, hemorrhages, ecchymosis, itching, inflammation of the joints, synovitis, joint effusion, stiffness of the joints, impaired joint mobility.These symptoms disappear within a few days if you let the joint rest and attach an ice pack. Only in rare cases, such reactions were more prolonged and serious. Hypersensitivity reactions, including anaphylactoid reactions, angioedema, skin reactions, including rash, pruritus, erythema, eczema, dermatitis, urticaria; very rarely - anaphylactic shock, but without lethal consequences; serum sickness; fever, heat sensation, headache, paresthesias. If a patient has a chronic inflammatory process in the acute stage, the use of hyaluronic acid in some individual cases worsened the patient's condition. Cases of bacterial arthritis and reactive arthritis have been observed at the site of intra-articular injection.

Hyaluronic acid interacts with some local anesthetics, extending their anesthetic effect.

Adults to appoint 2 ml of the drug by intra-articular injection 1 time per week for 3 weeks. Children. Do not apply.


The phenomena associated with cases of overdose, currently not recorded.

Injection. Main physical and chemical properties: transparent viscous solution without visible foreign inclusions.

Special notes

It is not recommended to use disinfectants,containing quaternary ammonium salts, since the contact with hyaluronic acid may form a precipitate; Intra-articular injection should be carried out by competent medical personnel in accordance with the established procedure under aseptic conditions necessary for this method of application. In some patients with inflammatory arthritis (rheumatoid arthritis or gouty arthritis), a transient increase in inflammation was observed after injection of the drug. If there is an articular effusion, it is recommended to perform aspiration before the administration of Hialubriks. It is recommended not to overload the joint for several hours after injection. Use during pregnancy or lactation. Despite the fact that no embryonic toxicity or teratogenic effects were observed in experiments conducted on animals, the use of the drug for pregnant women and mothers who breastfeed should be limited, except for cases that the doctor estimated were absolutely necessary, and only after a careful assessment of the ratio risk / benefit.

Storage conditions

Store in the original packaging out of the reach of children at a temperature not exceeding 25 ° C.

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