TROXIMETHACIN GEL 40G
TROXIMETHACIN GEL 40G
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Active ingredient and dosage form
1 g of the drug contains:
- active ingredients: Indomethacin 30 mg, Troxerutin 20 mg;
- excipients: carbomer 15 mg, disodium edetate 0.5 mg, sodium benzoate 2.5 mg, macrogol-400 522 mg, isopropanol 150 mg, dimethyl sulfoxide 150 mg, purified water 110 mg.
Gel for external use.
40 g in aluminum tubes, with an internal lacquer coating, lithographed outer surface, membrane and sealing ring, with a plastic screw cap.
Each tube together with instructions for use are placed in a cardboard box.
Uniform, transparent gel from yellow to yellow-brown color for external use.
Mechanism of action
Anti-inflammatory agent for local use
The gel base used provides the solubility and release of the drug components Indomethacin and Troxerutin.
Gel dosage form, which includes indomethacin and troxerutin, is well absorbed from the skin surface and provides a therapeutic effect of the drug.
When applied to the skin in the subcutaneous tissue and periarticular tissues are concentrations close to therapeutic.The penetration of active ingredients into the systemic circulation is clinically insignificant.
The combined preparation for topical administration, which consists of indomethacin and troxerutin.
Indomethacin has a pronounced anti-inflammatory, analgesic and anti-edema effect, leading to pain relief, reduction of edema and shortening the recovery time of affected tissues. The main mechanism of action is associated with the suppression of the synthesis of prostaglandins by reversible blockade of cyclooxygenase 1 and 2.
Troxerutin (trihydroxyethyl rutinoside) is a bioflavonoid. It has an angioprotective effect. Reduces capillary permeability and shows venotonic action. Blocks the venodilating action of histamine, bradykinin and acetylcholine. It acts anti-inflammatory on the near-venous tissue, reduces capillary fragility and has some antiplatelet effect. Reduces swelling, improves trophism in various pathological changes associated with venous insufficiency.
Troximethacin gel, when applied to the skin, suppresses the inflammatory edematous reaction, reduces pain and temperature in the foci of inflammation on the surface and in depth, reaching the blood vessels located there. It has a pronounced venotonic, capillary-protective effect.
Indications and usage
For symptomatic treatment:
- in the treatment of chronic venous insufficiency of the lower extremities (varicose veins) - to relieve swelling, feelings of heaviness and pain in the legs;
- superficial thrombophlebitis, phlebitis; post-phlebitis states;
- rheumatic soft tissue damage: tendovaginitis, bursitis, fibrositis, periarthritis;
- postoperative edema, contusions, sprains, sprains.
- Hypersensitivity to the drug;
- hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs);
- III trimester of pregnancy and breastfeeding;
- children's age up to 14 years (due to the lack of clinical experience of use);
- violation of the integrity of the skin.
With care: Simultaneous use of the drug with other NSAIDs, bronchial asthma, allergic rhinitis, nasal mucous polyps.
Tolerability of the drug is usually very good.
You may experience symptoms of hypersensitivity on the part of the skin - contact dermatitis, itching, redness, rash, a feeling of warmth and burning at the place of use.
The gel can enhance the effect of drugs that cause photosensitivity.
Clinically significant interactions with other drugs are not described.
The gel is applied externally.
3-4 times a day by rubbing the gel with a thin layer into the skin of painful areas of the body.The amount required for a single rubbing is about 4-5 cm of gel squeezed out of a tuba. The total daily amount should not exceed 20 cm of gel. The duration of treatment should not exceed 10 days.
There is no information about cases of overdose with local use.