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ZODAC PILLS 10MG -10 tablets



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Zodac 10mg Tab N10

Mechanism of action

Antiallergic drug, histamine H blocker1-receptors. Cetirizine belongs to the group of competitive histamine antagonists. It has a pronounced antiallergic effect, prevents the development and facilitates the course of allergic reactions. It has antipruritic and antiexudative effect. Affects the early stage of allergic reactions, and also reduces the migration of inflammatory cells; inhibits the release of mediators involved in the late allergic reaction. Reduces capillary permeability, prevents the development of tissue edema, relieves spasm of smooth muscles. Eliminates skin reactions to the introduction of histamine, specific allergens, as well as cooling (with cold urticaria).

Practically no anticholinergic and antiserotonin action.

In therapeutic doses, almost no sedative effect. Against the background of admission course tolerance does not develop.

The effect of the drug begins after 20 minutes (in 50% of patients) or after 1 hour (in 95% of patients) and lasts for 24 hours.



After oral administration, cetirizine is rapidly and almost completely absorbed from the gastrointestinal tract. Cmax in blood plasma is determined in about 30-60 minutes.Food intake does not have a significant effect on the amount of absorption, but in this case, the rate of absorption decreases slightly.


Cetirizine binding to plasma proteins is about 93%. V valued low - 0.5 l / kg. Cetirizine does not penetrate the cell. Does not penetrate the BBB.


Cetirizine is poorly metabolized in the liver to form an inactive metabolite.

With a 10-day use in a dose of 10 mg cumulation is not observed.


After a single dose of T1/2 is about 10 hours. About 70% is excreted by the kidneys mostly unchanged. The system clearance is about 54 ml / min.

Pharmacokinetics in special clinical situations

In children aged 2 to 12 years T1/2 reduced to 5-6 hours

When renal dysfunction (CC from 11 to 31 ml / min) and in patients on hemodialysis (CC less than 7 ml / min), T1/2 increases by 3 times, the clearance is reduced by 70%.

Against the background of chronic diseases and in elderly patients, there is an increase in T1/2 by 50% and decrease in clearance by 40%.

Cetirizine is not excreted by hemodialysis.


- seasonal and perennial allergic rhinitis and conjunctivitis;

- pruritic allergic dermatosis;

- pollinosis (hay fever);

- urticaria (including chronic idiopathic);

- Quincke swelling.

The drug is prescribed by mouth, regardless of the meal. Before taking the drops dissolve in water.

- 10 mg of cetirizine (20 drops or 2 measuring spoons of syrup) 1 time per day, daily, preferably in the evening.

- 10 mg of cetirizine (20 drops or 2 measuring spoons of syrup) 1 time per day or 5 mg of cetirizine (10 drops or 1 measuring spoon) 2 times / day - in the morning and evening.

- 5 mg of cetirizine (10 drops or 1 measuring spoon of syrup) 1 time / day or 2.5 mg of cetirizine (5 drops or 1/2 measuring spoon of syrup) 2 times / day in the morning and evening.

- 2.5 mg (5 drops) 2 times / day.

At renal failure should reduce the recommended dose by 2 times.

At abnormal liver function the dose should be selected individually, reducing it to 5 mg / day or less, with extreme caution with simultaneous renal failure.

Elderly patients with normal renal function dose adjustment is not required.

The bottle is closed with a lid with a safety device that prevents its opening by children. The bottle opens by pressing the cap down and then unscrewing it counterclockwise. After use, close the bottle cap tightly.

Side effect

Gastrointestinal: dry mouth, dyspepsia.

From the side of the central nervous system: headache, drowsiness, fatigue, dizziness, agitation, migraine.

Allergic reactions: skin rash, angioedema, urticaria, pruritus.

The drug is usually well tolerated. Side effects are rare and have a transient nature.


- pregnancy;

- lactation period;

- children's age up to 1 year (drops for oral administration);

- children's age up to 2 years (syrup);

- hypersensitivity to the drug.

WITH caution used in case of chronic renal failure of moderate and severe severity (correction of the dosing regimen is required), in elderly patients (reduction of glomerular filtration is possible).

Use during pregnancy and lactation

The drug is contraindicated in pregnancy and lactation.

Application for violations of the liver

At abnormal liver function the dose should be selected individually, reducing it to 5 mg / day or less, with extreme caution with simultaneous renal failure

Application for violations of kidney function

At renal failure should reduce the recommended dose by 2 times.

special instructions

Not recommended simultaneous medications that have a depressant effect on the central nervous system, and alcohol consumption.

Instructions for diabetics

Drops for oral administration do not contain sugar (saccharin is used as a sweetener), so this dosage form can be administered to patients with diabetes mellitus.

10 ml of syrup (2 scoops) contains 3 g of sorbitol, which corresponds to 0.25 XE.

Influence on ability to drive motor transport and control mechanisms

During the period of treatment, it is necessary to refrain from engaging in potentially hazardous activities that require high concentration of attention and quickness of psychomotor reactions.


Symptoms: drowsiness, lethargy, weakness, headache, tachycardia, irritability, urinary retention, fatigue are possible (more often when taking cetirizine in a dose of 50 mg / day).

Treatment: gastric lavage, the appointment of Activated carbon, conducting symptomatic therapy. The specific antidote is not revealed. Hemodialysis is ineffective.

Drug interaction

No clinically significant interaction of cetirizine with other drugs has been established.

Combined use with theophylline (400 mg / day) leads to a decrease in the total clearance of cetirizine (the kinetics of theophylline does not change).

Pharmacy sales terms

The drug is approved for use as a means of OTC.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature below 25 ° C. The shelf life of the drug in the form of drops for oral administration - 2 years, in the form of syrup - 3 years.

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