GLUCOPHAGE LONG PILLS 750MG

Extended Release Tablets

Composition

1 pill contains Metformin hydrochloride 750 mg;
Excipients: Povidone K30, Magnesium stearate, hypromellose.

Packing

30 pieces

Mechanism of action

Glucophage Long is an oral hypoglycemic drug from the biguanide group.
Increases the sensitivity of peripheral receptors to insulin and stimulates glucose uptake by muscle cells. Inhibits gluconeogenesis in the liver. Delays the absorption of carbohydrates in the intestines. It has a beneficial effect on lipid metabolism: lowers total cholesterol, triglycerides and LDL.
Glucophage long reduces hyperglycemia, without leading to the development of hypoglycemia, does not stimulate insulin secretion and does not have a hypoglycemic effect in healthy individuals.

Indications and usage

Type 2 diabetes mellitus (non-insulin-dependent) in adults with the ineffectiveness of diet therapy (especially with concomitant obesity);
In combination with insulin in type 2 diabetes mellitus (non-insulin-dependent), especially in severe obesity with secondary insulin resistance.

Contraindications

- diabetic ketoacidosis, coma, precoma;
- renal dysfunction;
- acute diseases at which there is a risk of development of a renal failure: dehydration, fever, severe infectious diseases, hypoxia (shock, sepsis, kidney infections, broncho-pulmonary diseases);
- Clinical manifestations of hypoxia (respiratory failure, heart failure, myocardial infarction);
- serious injuries and surgical interventions (when insulin therapy is indicated);
- abnormal liver function;
- chronic alcoholism and acute alcohol poisoning;
- lactic acidosis (including a history);
- a period of 2 days before and within 2 days after conducting radioisotope or x-ray studies with the introduction of iodine-containing contrast media;
- compliance with a low-calorie diet (less than 1000 kcal / day);
- pregnancy;
- lactation;
- Hypersensitivity to the drug Glucophage Long.
It is not recommended to use the drug in patients older than 60 years who perform heavy physical work, which is associated with an increased risk of developing lactic acidosis in them.

Dosage and administration

The initial dose of Glucophage long is 0.5-1 g / day. After 10-15 days, a further gradual increase in dose is possible depending on the level of hypoglycemia. Maintenance dose of the drug averages 1.5-2 g / day. The maximum dose - 3 g / day.
To reduce side effects from the gastrointestinal tract, the daily dose should be divided into 2-3 doses.
Tablets should be taken whole, during or immediately after a meal.

Adverse reactions

Gastrointestinal: nausea, vomiting, diarrhea, metallic taste in the mouth, lack of appetite, flatulence, abdominal pain (most often occur at the beginning of therapy and pass on their own).
Metabolism: lactic acidosis (requires discontinuation of the drug); with prolonged use - vitamin B12 hypovitaminosis (impaired absorption).
From the hemopoietic system: in some cases - megaloblastic anemia.
Allergic reactions: skin rash.

The side effects of the digestive system can be reduced by prescribing antacids, atropine derivatives, or antispasmodics. To avoid the development of these side effects, it is recommended that Glucophage Long be prescribed at a time or at the end of a meal 2-3 times a day. With persistent dyspepsia, Glucophage should be canceled.
During the period of use of the drug is recommended to monitor the function of the liver and kidneys.
Glucophage long should be canceled 48 hours before and during the period of 48 hours after the X-ray examination with the use of radiopaque agents.
Against the background of the use of the drug Glucophage long should not drink alcohol and ethanol-containing drugs.

Drug Interactions

Symptoms: When using the Glucophage Long at a dose of 85 g, hypoglycemia was not observed, but the development of lactic acidosis was noted.Early symptoms of lactic acidosis are nausea, vomiting, diarrhea, fever, pain in the abdomen, muscle pain, further, increased breathing, dizziness, impaired consciousness, the development of coma.
Treatment: immediate cancellation of Glucophage long, urgent hospitalization, determination of lactate concentration in the blood; if necessary, conduct symptomatic therapy. For removal of lactate and metformin from the body, hemodialysis is most effective.

Storage conditions

Keep out of reach of children at a temperature of 15 ° to 25 ° C.

2 years.