TOPAMAX CAPSULES 50MG

Capsules

Dosage and administration

The drug is taken orally, regardless of the meal. The capsules should be carefully opened, mix their contents with a small amount (about 1 teaspoon) of any soft food. This mixture should be swallowed immediately, without chewing. Do not store the drug mixed with food until the next dose. Capsules Topamax can be swallowed whole.
Epilepsy: in order to achieve optimal control of epileptic seizures in adults and children, it is recommended to begin treatment by taking the drug in low doses, followed by titration to an effective dose. Capsules are intended for patients who have difficulty swallowing pills (for example, in children and elderly patients).
When conducting monotherapy: adults, including elderly patients with normal renal function, at the beginning of treatment, Topamax is prescribed 25 mg 1 time / day at bedtime for 1 week. Then the dose is increased with an interval of 1-2 weeks at 25-50 mg / day in 2 doses. In case of intolerance to such a treatment regimen, the dose is increased by a smaller amount or at long intervals. The criterion for the selection of the dose is the clinical effect. The initial dose is 100 mg / day, the maximum daily dose is 500 mg. In some cases, with a refractory form of epilepsy, patients tolerate monotherapy with Topamax at doses up to 1 g / day.For children older than 2 years in the first week of treatment, Topamax is prescribed at a dose of 0.5-1 mg / kg of body weight at bedtime. Then the dose is increased with an interval of 1-2 weeks by 0.5-1 mg / kg / day, the daily dose is divided into 2 doses. In case of intolerance to such a regimen, the dose can be increased by a smaller amount or at large intervals. The magnitude of the dose and the rate of its increase are determined by the clinical efficacy of therapy. The recommended dose range for monotherapy with topiramate in children older than 2 years is 3-6 mg / kg / day. With newly diagnosed partial seizures, the dose can be up to 500 mg / day.
When using the drug Topamax as part of combination therapy with other anticonvulsants: in adults, including elderly patients with normal renal function, the minimum effective dose is 200 mg / day. The average daily dose is 200-400 mg, the multiplicity of reception - 2 times / day. Selection of the dose begins with 25-50 mg 1 time / day at night, the drug is taken within 1 week. Further, the dose should be increased by 25-50 mg at intervals of 1 or 2 weeks prior to the selection of the effective dose; a frequency rate of reception - 2 times / days. If necessary, you can increase the daily dose to the maximum - 1600 mg. The criterion for the selection of the dose is the clinical effect. In some patients, the effect is achieved when taking the drug 1 time / day. To achieve the optimal effect of treatment with Topamax, it is not necessary to control its plasma concentration. In children older than 2 years, the recommended total daily dose is from 5 to 9 mg / kg, the frequency of administration is 2 times / day.The selection of the dose begins with 25 mg / day (or less, at the rate of 1-3 mg / kg body weight / day), the drug is taken overnight for 1 week. In the future, with weekly or two-week intervals, the dose can be increased by 1-3 mg / kg and take the drug in 2 doses. When selecting the dose should be guided by the clinical effect. A daily dose of up to 30 mg / kg body weight is generally well tolerated.
When canceling concomitant anticonvulsant drugs for the purpose of monotherapy with topiramate, it is necessary to consider the possible influence of this step on the frequency of seizures. In cases where there is no need to abruptly cancel the concomitant anticonvulsant drug for safety reasons, it is recommended to reduce their dose gradually, reducing the dose of the concomitant anti-epileptic drug by one third every 2 weeks. With the abolition of drugs that are inducers of liver enzymes, the concentration of topiramate in the blood will increase. In such situations, in the presence of clinical indications, the dose of Topamax can be reduced.
For the prevention of migraine attacksThe daily dose of topiramata is 100 mg in 2 divided doses. At the beginning of treatment, 25 mg is prescribed at bedtime for 1 week. Then the dose is increased by 25 mg / day with an interval of 1 week. In case of intolerance to such a treatment regimen, the dose is increased by a smaller amount or at long intervals. The dose is selected depending on the clinical effect. In some cases, a positive result is achieved with a daily dose of topiramate 50 mg. In clinical studies, patients received various doses of topiramate, but not more than 200 mg / day.