SERTAMICOL CREAM 2% 20G
SERTAMICOL CREAM 2% 20G
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Mechanism of action
Sertamicol - antifungal agent for external and local use. Sertaconazole is an imidazole and benzothiophene derivative with a broad spectrum of activity against pathogenic fungi Candida spp. (including Candida albicans, Candida tropicalis), other pathogenic fungi (Pityrosporum orbiculare, Malassezia spp.), dermatophytes (Trichophyton and Microsporum), Gram-positive bacteria (Streptococcus spp., Staphylococcus spp.), as well as Gardnere-agde vidrum and anti-viral and anti-viral and anti-viral ecoprosis. faecalis, Bacteroides spp., Trichomonas vaginalis.
Sertaconazole does not inhibit the viability of Lactobacillus spp. in vitro.
In therapeutic doses has a fungicidal and fungistatic effect. The mechanism of action of sertaconazole is to suppress the synthesis of ergosterol, the main component of the membranes of fungal cells and in competitive antagonism with another component of the cell wall, tryptophan. This leads to disorganization and an increase in the permeability of the cell membrane, destruction and destruction of the pathogenic microorganism.
The therapeutic concentration of sertaconazole in the stratum corneum of the skin after application to the skin is reached within 30 minutes and lasts more than 48 hours. With daily use for 14 days in increasing amounts, sertaconazole is not detected in the blood and urine.
After intravaginal use, high concentrations of sertaconazole in the lumen of the vagina persist for a long time and significantly exceed both the minimum inhibitory concentrations and fungicidal concentrations in relation to C.albicans, C.glabrata, and other fungi other than the genus Candida. Systemic absorption after intravaginal use is absent. Unchanged sertaconazole is not detected either in the blood plasma or in the urine.
Indications and usage
Superficial mycoses of the skin - dermatophytosis, incl. Stop(Tinea pedis), torso(Tinea corporis), beards(Tinea barbae); candidiasis, multi-colored versicolor.
Hypersensitivity to sertaconazole, imidazole derivative.
1 g of cream contains:
Active substance: sertaconazole nitrate; 0.02 g;
Excipients: cetyl alcohol 0.035 g, stearyl alcohol 0.035 g, myristyl alcohol 0.02 g, glyceryl monostearate 0.02 g, sorbitan stearate 0.01 g, polysorbate 60 0.035 g, octyldodecanol 0.04 g, liquid paraffin 0.04 g, benzyl alcohol 0.01 g, purified water 93%, purified water 0.04 g
Dosage and administration
Externally used 1-2 times a day for 2-4 weeks.
Fast passing local erythematous reaction.
In the dark place at a temperature of 2-25 ° C. (in tightly closed package)